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Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues

2001Journal article Metadata only
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dc.contributor.authorMarco, JL
dc.contributor.authorde los Rios, C
dc.contributor.authorCarreiras, MC
dc.contributor.authorBanos, JE
dc.contributor.authorBadia, A
dc.contributor.authorVivas, NM
dc.date.accessioned2015-12-30T10:18:02Z
dc.date.available2015-12-30T10:18:02Z
dc.date.issued2001
dc.description.abstractThe synthesis and preliminary results for acetylcholinesterase and butyrylcholinesterase inhibition activity of a series of pyrano[2,3-b]quinolines (2, 3) and benzonaphthyridines (5, 6) derivatives are described. These molecules are tacrine-like analogues which have been prepared from readily available polyfunctionalized ethyl [6-amino-5-cyano-4H-pyrans and 6-amino-5-cyanopyridine s]-3-carboxylates via Friedlander condensation with selected ketone s. These compounds showed moderate acetylcholinesterase inhibition activity, the more potent (2e, 5b) being 6 times less active than tacrine. The butyrylcholinesterase activity of some of these molecules is also discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.
dc.formatapplication/pdf
dc.identifier.citationBIOORGANIC & MEDICINAL CHEMISTRY. - Vol. 9, n. 3 (MAR 2001), p. 727-732
dc.identifier.issn0968-0896
dc.identifier.urihttp://hdl.handle.net/10451/21378
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.subjectBiochemistry & Molecular Biology
dc.subjectChemistry, Medicinal
dc.subjectChemistry, Organic
dc.titleSynthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage732por
oaire.citation.startPage727por
oaire.citation.titleBIOORGANIC & MEDICINAL CHEMISTRYpor
oaire.citation.volumeVol. 9por
rcaap.rightsrestrictedAccess
rcaap.typearticle

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