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Glutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicity

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dc.contributor.authorGonçalves-Ribeiro, Joana
dc.contributor.authorPina, Carolina Campos
dc.contributor.authorSebastião, Ana M
dc.contributor.authorVaz, Sandra H.
dc.date.accessioned2022-04-28T16:29:23Z
dc.date.available2022-04-28T16:29:23Z
dc.date.issued2019
dc.descriptionCopyright © 2019 Gonçalves-Ribeiro, Pina, Sebastião and Vaz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractGlutamate uptake is a process mediated by sodium-dependent glutamate transporters, preventing glutamate spillover from the synapse. Typically, astrocytes express higher amounts of glutamate transporters, thus being responsible for most of the glutamate uptake; nevertheless, neurons can also express these transporters, albeit in smaller concentrations. When not regulated, glutamate uptake can lead to neuronal death. Indeed, the majority of the studies regarding glutamate transporters have focused on excitotoxicity and the subsequent neuronal loss. However, later studies have found that glutamate uptake is not a static process, evincing a possible correlation between this phenomenon and the efficiency of synaptic transmission and plasticity. In this review, we will focus on the role of the increase in glutamate uptake that occurs during long-term potentiation (LTP) in the hippocampus, as well as on the impairment of long-term depression (LTD) under the same conditions. The mechanism underpinning the modulatory effect of glutamate transporters over synaptic plasticity still remains unascertained; yet, it appears to have a more prominent effect over the N-methyl-D-aspartate receptor (NMDAR), despite changes in other glutamate receptors may also occur.pt_PT
dc.description.sponsorshipThis work was supported by UID/BIM/50005/2019 [project finnanced by Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through Fundos do Orçamento de Estado] and PTDC/BTM-SAL/32147/2017 (FCT). JG-R was in receipt of an FCT fellowship (iMM/BI/96-2018).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Cell Neurosci. 2019 Aug 6;13:357pt_PT
dc.identifier.doi10.3389/fncel.2019.00357pt_PT
dc.identifier.eissn1662-5102
dc.identifier.urihttp://hdl.handle.net/10451/52590
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationInstituto de Medicina Molecular
dc.relationAstrosomes: Artificial Astrocytes as a Novel Approach to Regulate Neuronal Communication
dc.relation.publisherversionhttps://www.frontiersin.org/journals/cellular-neuroscience#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNMDARpt_PT
dc.subjectAstrocytespt_PT
dc.subjectGlutamate transporterspt_PT
dc.subjectSynaptic plasticitypt_PT
dc.subjectTripartite synapsept_PT
dc.titleGlutamate transporters in hippocampal LTD/LTP: not just prevention of excitotoxicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstituto de Medicina Molecular
oaire.awardTitleAstrosomes: Artificial Astrocytes as a Novel Approach to Regulate Neuronal Communication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F50005%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-SAL%2F32147%2F2017/PT
oaire.citation.titleFrontiers in Cellular Neurosciencept_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNameGonçalves Ribeiro
person.familyNameSebastião
person.familyNameHenriques Vaz
person.givenNameJoana Filipa
person.givenNameAna M
person.givenNameSandra Cristina
person.identifier.ciencia-id3018-692A-C792
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.ciencia-id0E1C-952D-61BE
person.identifier.orcid0000-0002-5194-6512
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0003-4258-9397
person.identifier.scopus-author-id7004409879
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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