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Technological Advances in Cutaneous Wound Repair
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A pele atua como a primeira linha de proteção contra o ambiente externo e fornece funções essenciais. Quando a sua integridade é comprometida devido a complicações mecânicas, físicas ou relacionadas com o metabolismo, é geralmente observado um maior risco de danos adicionais. Além disso, vários fatores levam ao comprometimento do processo de cicatrização, o que pode levar a feridas crónicas e, consequentemente, causar sofrimento, aumentar a suscetibilidade a infeções e diminuir a qualidade de vida dos doentes. A presente tese de mestrado descreve brevemente a anatomia e fisiologia da pele, as mudanças estruturais e funcionais desta ao longo do tempo, a patogénese das feridas crónicas e as abordagens terapêuticas desenvolvidas para tratar infeções e estimular o processo de cicatrização. Assim, nesta tese de mestrado, focámo-nos em terapias mais tradicionais (como por exemplo, enxertos e pensos) e em abordagens inovadoras, das quais fazem parte os substitutos cutâneos e sistemas nanotecnológicos. Outros tipos de estratégias avançadas no tratamento de feridas incluem terapias com células estaminais e fatores de crescimento, terapia génica, terapia por pressão negativa, oxigenoterapia hiperbárica e outras. De forma geral, esta dissertação cobre os recentes avanços tecnológicos nas duas últimas décadas e discute possíveis perspetivas no tratamento de feridas.
The skin acts as the first line of protection against environmental exposure and provides essential functions. When its integrity is compromised due to mechanical, physical or metabolism-related issues, a higher risk of further damage is commonly observed. Besides, several factors lead to impaired wound healing, which may lead to chronic wounds and consequently cause suffering, increase the susceptibility of infections, and decrease the quality of life of patients. The present master thesis briefly describes the anatomy and physiology of the skin, the structural and functional changes over time, chronic wound pathogenesis and therapeutic approaches designed to treat infections and stimulate the healing process. Hence, in this master thesis, we focused on both traditional therapies (e.g. grafts and wound dressings) and innovative approaches, including engineered skin substitutes and nano-based drug delivery systems. Other types of advanced wound care strategies include stem cells therapies, growth factors therapies, gene therapy vectors, negative pressure wound therapy, hyperbaric oxygen therapy and others. This overview covers the latest advancements in the past two decades and discusses possible prospects in wound management.
The skin acts as the first line of protection against environmental exposure and provides essential functions. When its integrity is compromised due to mechanical, physical or metabolism-related issues, a higher risk of further damage is commonly observed. Besides, several factors lead to impaired wound healing, which may lead to chronic wounds and consequently cause suffering, increase the susceptibility of infections, and decrease the quality of life of patients. The present master thesis briefly describes the anatomy and physiology of the skin, the structural and functional changes over time, chronic wound pathogenesis and therapeutic approaches designed to treat infections and stimulate the healing process. Hence, in this master thesis, we focused on both traditional therapies (e.g. grafts and wound dressings) and innovative approaches, including engineered skin substitutes and nano-based drug delivery systems. Other types of advanced wound care strategies include stem cells therapies, growth factors therapies, gene therapy vectors, negative pressure wound therapy, hyperbaric oxygen therapy and others. This overview covers the latest advancements in the past two decades and discusses possible prospects in wound management.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2019
Palavras-chave
Chronic wounds Wound healing Wound dressings Skin tissue engineering Nanotechnology. Mestrado Integrado - 2019