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Implications of nitrosative stress in apoptotic cascades mediated by pro-inflammatory cytokines in immature neurons
| dc.contributor.author | Vaz, A. R. | |
| dc.contributor.author | Leitão Silva, S. | |
| dc.contributor.author | Barateiro, A. | |
| dc.contributor.author | Fernandes, A. | |
| dc.contributor.author | Falcão, A. S. | |
| dc.contributor.author | Silva, R. F. M. | |
| dc.contributor.author | Brito, M. A. | |
| dc.contributor.author | Brites, D. | |
| dc.date.accessioned | 2015-12-30T10:18:41Z | |
| dc.date.available | 2015-12-30T10:18:41Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | The inflammatory response is essential for survival in response to tissue injury or infection, but it can also cause neuronal damage [1]. In fact, pro-inflammatory cytokines, as well as nitric oxide (NO), are known as mediators of neuronal apoptosis [2,3]. Although apoptosis occurs physiologically in the brain during the period of the growth spurt, an increase in the number of neurons undergoing apoptosis may produce neuropathological sequelae [4]. Therefore, the aim of the present study was to: (i) deepen characterize the mechanisms of neuronal apoptosis upon cytokine exposure in neuronal immature cells; and (ii) investigate the role of NO as a determinant. | |
| dc.description.sponsorship | Funded by FCT-PPCDT/SAU-MMO/55955/2004 and FCT-PTDC/SAU-NEU/64385/2006 (to DB) | |
| dc.format | application/pdf | |
| dc.identifier.citation | Frontiers in Neuroscience Conference Abstract | |
| dc.identifier.doi | http://dx.doi.org/10.3389/conf.neuro.01.2009.11.075 | |
| dc.identifier.uri | http://hdl.handle.net/10451/21730 | |
| dc.language.iso | eng | |
| dc.publisher | Frontiers | |
| dc.title | Implications of nitrosative stress in apoptotic cascades mediated by pro-inflammatory cytokines in immature neurons | |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Frontiers in Neuroscience Conference Abstract | por |
| rcaap.rights | restrictedAccess | |
| rcaap.type | conferenceObject |
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