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HIV-1 genetic diversity and transmitted drug resistance in health care settings in Maputo, Mozambique

2009Artigo científico Acesso restrito
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dc.contributor.authorBártolo, Inês
dc.contributor.authorCasanovas, José
dc.contributor.authorBastos, Rui
dc.contributor.authorRocha, Cheila
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorFolgosa, Elena
dc.contributor.authorMondlane, José
dc.contributor.authorManuel, Rolanda
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2025-08-14T23:38:24Z
dc.date.available2025-08-14T23:38:24Z
dc.date.issued2009
dc.date.updated2023-02-03T14:42:22Z
dc.description.abstractObjectives: To characterize HIV-1 diversity and transmitted drug resistance in persons with access to care and treatment in Maputo, Mozambique. Methods: Samples were collected in 2002-2004 from 144 drug-naive patients attending public hospitals and private clinics. Plasma viremia, CD4, and CD8 cell counts were determined for each patient. The Stanford Algorithm was used for resistance genotyping on pol sequences. Subtyping was done by phylogenetic analysis. Results: Most patients had high viral load (mean, 5.0 log copies/mL) and low CD4 cell counts (median, 260 CD4 cells/μL). Protease and/or reverse transcriptase sequences were obtained from 104 (72%) samples. Patients harbored subtypes C (80.8%), G (3.8%), CRF37_cpx (6.7%), untypable (U) (1.0%), and recombinant strains (7.7%) comprising the A, C, D, F, and U clades. There were no major protease inhibitor resistance mutations. Mutations conferring resistance to the nucleoside/nucleotide reverse transcriptase inhibitors and/or nonnucleoside reverse transcriptase inhibitors were found in 4 (4/68; 5.9%) patients. Phylogenetic analysis suggested an imported origin for 2 resistant variants. Conclusions: The HIV-1 epidemic in Maputo is evolving rapidly in genetic complexity due to the recent introduction of all major subtypes and recombinant forms. Continued surveillance of drug resistance in treated and untreated populations is needed to prevent further transmission of HIV drug-resistant variants and maximize the efficacy of antiretroviral therapy in Maputo.pt_PT
dc.description.sponsorshipSupported by Fundação para a Ciência e Tecnologia, Portugal (project PSIDA/ESP/49699). I.B., C.R., and A.B.A. are supported by PhD grants from Fundação para a Ciência e Tecnologia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBártolo I, Casanovas J, Bastos R, Rocha C, Abecasis AB, Folgosa E, et al. HIV-1 Genetic Diversity and Transmitted Drug Resistance in Health Care Settings in Maputo, Mozambique. JAIDS Journal of Acquired Immune Deficiency Syndromes 2009;51:323–31. https://doi.org/10.1097/QAI.0b013e3181a24906.pt_PT
dc.identifier.doi10.1097/QAI.0b013e3181a24906pt_PT
dc.identifier.eid2-s2.0-67651031262
dc.identifier.slugcv-prod-1108467
dc.identifier.urihttp://hdl.handle.net/10400.5/102930
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLippincott / Wolters Kluwerpt_PT
dc.relation.publisherversionhttps://journals.lww.com/jaids/abstract/2009/07010/hiv_1_genetic_diversity_and_transmitted_drug.13.aspxpt_PT
dc.subjectHIV-1 infection in Maputopt_PT
dc.subjectHIV-1 genetic formspt_PT
dc.subjecttransmitted HIV-1 drug resistancept_PT
dc.titleHIV-1 genetic diversity and transmitted drug resistance in health care settings in Maputo, Mozambiquept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage331pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage323pt_PT
oaire.citation.titleJournal of Acquired Immune Deficiency Syndromespt_PT
oaire.citation.volume51pt_PT
person.familyNameBártolo
person.familyNameTaveira
person.givenNameInês
person.givenNameNuno
person.identifier318426
person.identifier476379
person.identifier.ciencia-id661E-F5CB-F85A
person.identifier.ciencia-id7111-3383-A926
person.identifier.orcid0000-0002-2022-8921
person.identifier.orcid0000-0003-0176-5585
person.identifier.ridA-7477-2014
person.identifier.ridA-6252-2014
person.identifier.scopus-author-id8418824400
person.identifier.scopus-author-id6602731390
rcaap.cv.cienciaid661E-F5CB-F85A | Inês Bártolo
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication17555d0a-4e10-49ce-b415-00fe51b57cfd
relation.isAuthorOfPublicationb57e2ea6-7336-4f8f-96a9-9ff4677829ee
relation.isAuthorOfPublication.latestForDiscoveryb57e2ea6-7336-4f8f-96a9-9ff4677829ee

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