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In vivo bio-distribution and toxicity evaluation of polymeric and lipid-based nanoparticles : a potential approach for chronic diseases treatment

2020Journal article Open access
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dc.contributor.authorFonseca-Gomes, João
dc.contributor.authorLoureiro, Joana A
dc.contributor.authorTanqueiro, Sara
dc.contributor.authorMouro, Francisco
dc.contributor.authorRuivo, Pedro
dc.contributor.authorCarvalho, Tânia
dc.contributor.authorSebastião, Ana M
dc.contributor.authorDiógenes, Maria José
dc.contributor.authorPereira, Maria Carmo
dc.date.accessioned2021-04-07T16:49:30Z
dc.date.available2021-04-07T16:49:30Z
dc.date.issued2020
dc.description© 2020 Fonseca-Gomes et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.pt_PT
dc.description.abstractNanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected.pt_PT
dc.description.sponsorshipThis work was financially supported by: 1) Base Funding - UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE – funded by national funds through the Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) (PIDDAC) funded by FEDER funds through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT/MCTES; 2) Santa Casa da Misericórdia de Lisboa (MB37-2017); 3) European Union’s Horizon 2020 research and innovation programme under grant agreement No 810685 (DelNAM). FCT supported J.F.G. (SFRH/PD/BD/114441/2016); S.R.T. (SFRH/PD/BD/128091/2016) and J.A.L under the Scientific Employment Stimulus – Institutional Call – [CEECINST/00049/2018].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Nanomedicine. 2020 Nov 5;15:8609-8621pt_PT
dc.identifier.doi10.2147/IJN.S267007pt_PT
dc.identifier.eissn1178-2013
dc.identifier.issn1176-9114
dc.identifier.urihttp://hdl.handle.net/10451/47280
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDovepresspt_PT
dc.relationSFRH/PD/BD/114441/2016pt_PT
dc.relationLaboratory for Process Engineering, Environment, Biotechnology and Energy
dc.relationStrengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis
dc.relation.publisherversionhttps://www.dovepress.com/international-journal-of-nanomedicine-journalpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectPLGA nanoparticlespt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectLiposomespt_PT
dc.subjectLong-lasting treatmentpt_PT
dc.subjectNanocarrierspt_PT
dc.subjectSolid lipid nanoparticlespt_PT
dc.titleIn vivo bio-distribution and toxicity evaluation of polymeric and lipid-based nanoparticles : a potential approach for chronic diseases treatmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory for Process Engineering, Environment, Biotechnology and Energy
oaire.awardTitleStrengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00511%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/810685/EU
oaire.citation.endPage8621pt_PT
oaire.citation.startPage8609pt_PT
oaire.citation.titleInternational Journal of Nanomedicinept_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamH2020
person.familyNameFonseca-Gomes
person.familyNameTanqueiro
person.familyNameMouro
person.familyNameRuivo
person.familyNameCarvalho
person.familyNameSebastião
person.familyNamede Oliveira Diógenes Nogueira
person.givenNameJoão
person.givenNameSara
person.givenNameFrancisco
person.givenNamePedro
person.givenNameTânia
person.givenNameAna M
person.givenNameMaria José
person.identifier548147
person.identifier.ciencia-idA217-D5D0-E9BF
person.identifier.ciencia-id6818-4322-9ED9
person.identifier.ciencia-id4C10-5743-02F8
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person.identifier.ciencia-id4B10-886B-DAFC
person.identifier.orcid0000-0001-7915-3517
person.identifier.orcid0000-0002-9151-7149
person.identifier.orcid0000-0002-7141-8418
person.identifier.orcid0000-0002-5419-4790
person.identifier.orcid0000-0002-5283-5013
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0001-5486-6246
person.identifier.ridJ-3656-2013
person.identifier.scopus-author-id25653983600
person.identifier.scopus-author-id7004409879
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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