Logo do repositório
 
Publicação

Gelastic seizures : a retrospective study in five tertiary hospital centres

2020Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorAmorim, Isabel Loução de
dc.contributor.authorPereira, Cristina
dc.contributor.authorSequeira, João
dc.contributor.authorRocha, Helena
dc.contributor.authorPeralta, Ana Rita
dc.contributor.authorRego, Ricardo
dc.contributor.authorBentes, Carla
dc.contributor.authorBento, Conceição
dc.contributor.authorSales, Francisco
dc.contributor.authorRobalo, Conceição
dc.contributor.authorPimentel, José
dc.date.accessioned2021-01-05T13:54:18Z
dc.date.available2021-01-05T13:54:18Z
dc.date.issued2020
dc.descriptionCopyright © 2020 John Libbey Eurotextpt_PT
dc.description.abstractThis study aimed to characterize, clinically and neurophysiologically, a series of patients with gelastic seizures (GS), including both adults and children. We retrospectively collected patients with GS from epilepsy clinics of five tertiary hospital centres within a single country. Patients were selected through relatives'/caregivers' descriptions, home video and/or video-EEG monitoring. GS were identified through ictal semiology. Thirty-five patients were enrolled; 62.9% had initial GS in infancy, 14.3% in adolescence and 22.8% at adult age. Twenty-six had abnormal MRI: eight presented with hypothalamic hamartoma (HH) and 16 non-HH lesions that included different structural aetiologies and genetic, metabolic and immune aetiologies. All patients with HH had their first GS in infancy or adolescence. For the remaining aetiologies, GS started in infancy in 59.3%, in adolescence in 11.1% and at adult age in 29.6%. Video-EEG data was available for analysis in 11 patients, including seven patients with a non-HH MRI lesion. The ictal onset topography on scalp video-EEG was usually concordant with the MRI lesion (in 6/7 patients) and the most frequent ictal onset was fronto-temporal. In two patients, both video-EEG and MRI suggested a parietal and occipital epileptogenic zone. Aetiologies and patterns of affected topography unrelated to HH are common in patients with GS, and all age groups may manifest with this type of ictal semiology. This ictal manifestation has no lateralizing value and, despite a clear preponderance for hypothalamic, frontal and temporal lobe origins, other brain areas, namely the parietal and occipital lobes, should be considered.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEpileptic Disord. 2020 Apr 1;22(2):165-175pt_PT
dc.identifier.doi10.1684/epd.2020.1153pt_PT
dc.identifier.eissn1950-6945
dc.identifier.issn1294-9361
dc.identifier.urihttp://hdl.handle.net/10451/45657
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Libbey Eurotextpt_PT
dc.relation.publisherversionhttps://www.jle.com/fr/revues/epd/revue.phtmlpt_PT
dc.subjectGelastic seizurespt_PT
dc.subjectHypothalamic hamartomapt_PT
dc.subjectVideo-EEGpt_PT
dc.titleGelastic seizures : a retrospective study in five tertiary hospital centrespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage175pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage165pt_PT
oaire.citation.titleEpileptic Disorderspt_PT
oaire.citation.volume22pt_PT
person.familyNameBentes
person.givenNameCarla
person.identifier.ciencia-id7D1C-D5DD-C579
person.identifier.orcid0000-0003-2399-7678
person.identifier.scopus-author-id6603395191
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0bc2f877-0ad3-408c-82ee-b5378a014734
relation.isAuthorOfPublication.latestForDiscovery0bc2f877-0ad3-408c-82ee-b5378a014734

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Gelastic_seizures.pdf
Tamanho:
1.27 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

FM - Artigos em Revistas Internacionais