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Inhibition of Plasmodium liver infection by Ivermectin

2017Journal article Open access
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dc.contributor.authorMendes, António M.
dc.contributor.authorAlbuquerque, Inês S.
dc.contributor.authorMachado, Marta
dc.contributor.authorPissarra, Joana
dc.contributor.authorMeireles, Patricia
dc.contributor.authorPrudêncio, Miguel
dc.date.accessioned2021-07-27T13:24:17Z
dc.date.available2021-07-27T13:24:17Z
dc.date.issued2017
dc.descriptionCopyright © 2017 Mendes et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.pt_PT
dc.description.abstractAvermectins are powerful endectocides with an established potential to reduce the incidence of vector-borne diseases. Here, we show that several avermectins inhibit the hepatic stage of Plasmodium infection in vitro Notably, ivermectin potently inhibits liver infection in vivo by impairing parasite development inside hepatocytes. This impairment has a clear impact on the ensuing blood stage parasitemia, reducing disease severity and enhancing host survival. Ivermectin has been proposed as a tool to control malaria transmission because of its effects on the mosquito vector. Our study extends the effect of ivermectin to the early stages of mammalian host infection and supports the inclusion of this multipurpose drug in malaria control strategies.pt_PT
dc.description.sponsorshipA.M.M., P.M., and M.P. acknowledge the Fundação para a Ciência e Tecnologia, Portugal, for grants SFRH/BPD/80693/2011, SFRH/BD/71098/2010, and Investigador FCT (2013), respectively. This work was supported by Fundação para a Ciência e Tecnologia (FCT, Portugal) grant PTDC/SAU-MIC/117060/2010.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAntimicrob Agents Chemother. 2017 Jan 24;61(2):e02005-16.pt_PT
dc.identifier.doi10.1128/AAC.02005-16pt_PT
dc.identifier.eissn1098-6596
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/10451/49163
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherASM Journalspt_PT
dc.relationEXPLORING HOST-PARASITE INTERACTIONS TO ESTABLISH A NEW WHOLE ORGANISM VACCINE AGAINST MALARIA
dc.relationNUTRIENT UPTAKE AND TRANSPORT BY THE MALARIA PARASITE IN THE LIVER
dc.relationUtilization of host cell resources by the malaria parasite in the liver
dc.relation.publisherversionhttps://journals.asm.org/journal/aacpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPlasmodiumpt_PT
dc.subjectAvermectinspt_PT
dc.subjectIvermectinpt_PT
dc.subjectLiver stagept_PT
dc.subjectMalariapt_PT
dc.titleInhibition of Plasmodium liver infection by Ivermectinpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEXPLORING HOST-PARASITE INTERACTIONS TO ESTABLISH A NEW WHOLE ORGANISM VACCINE AGAINST MALARIA
oaire.awardTitleNUTRIENT UPTAKE AND TRANSPORT BY THE MALARIA PARASITE IN THE LIVER
oaire.awardTitleUtilization of host cell resources by the malaria parasite in the liver
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F80693%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F71098%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-MIC%2F117060%2F2010/PT
oaire.citation.issue2pt_PT
oaire.citation.titleAntimicrobial Agents and Chemotherapypt_PT
oaire.citation.volume61pt_PT
oaire.fundingStreamOE
oaire.fundingStream3599-PPCDT
person.familyNameM. Mendes
person.familyNameS. Albuquerque
person.familyNamePissarra
person.familyNameMeireles
person.familyNamePrudêncio
person.givenNameAntónio
person.givenNameInês
person.givenNameJoana
person.givenNamePatricia
person.givenNameMiguel
person.identifier361994
person.identifier350738
person.identifierhttps://scholar.google.pt/citations?user=zduN6wsAAAAJ&hl=pt-PT&oi=ao
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person.identifier.orcid0000-0001-6562-5325
person.identifier.orcid0000-0002-1108-0961
person.identifier.orcid0000-0002-0506-8042
person.identifier.orcid0000-0002-9188-2808
person.identifier.orcid0000-0003-1746-6029
person.identifier.ridP-5325-2016
person.identifier.scopus-author-id14028767900
person.identifier.scopus-author-id57189632581
person.identifier.scopus-author-id6603561872
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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