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Contingent negative variation: a biomarker of abnormal attention in functional movement disorders

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dc.contributor.authorTeodoro, Tiago
dc.contributor.authorKoreki, A.
dc.contributor.authorMeppelink, A. M.
dc.contributor.authorLittle, S.
dc.contributor.authorNielsen, G.
dc.contributor.authorMacerollo, A.
dc.contributor.authorFerreira, Joaquim J
dc.contributor.authorPareés, I.
dc.contributor.authorLang, A.
dc.contributor.authorEdwards, M. J.
dc.date.accessioned2021-12-15T15:38:57Z
dc.date.available2021-12-15T15:38:57Z
dc.date.issued2020
dc.description© 2020 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractBackground and purpose: Contingent negative variation (CNV) is a negative cortical wave that precedes a pre-cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention. The aim was to ascertain whether the clinical improvement of functional movement disorders after physiotherapy would be associated with faster reaction times and modulation of CNV. Methods: Motor performance and CNV were analysed during a pre-cued choice reaction time task with varying cue validity. Twenty-one patients with functional movement disorders and 13 healthy controls at baseline were compared. Patients then underwent physiotherapy. At follow-up after physiotherapy, patients were categorized as clinically improved (responders) or not improved (non-responders) and retested. Results: At baseline, patients did not generate CNV, contrary to controls [mean amplitude (µV) at the end of preparation to move: patients -0.47 (95% CI -1.94, 1.00) versus controls -2.59 (95% CI -4.46, -0.72)]. Responders performed faster after physiotherapy [mean natural logarithm (ln) reaction time (RT) (ms): follow-up 6.112 (95% CI 5.923, 6.301) versus baseline 6.206 (95% CI 6.019, 6.394), P = 0.010], contrary to non-responders. Simultaneously, responders showed a recovery of CNV after physiotherapy [follow-up -1.95 (95% CI -3.49, -0.41) versus baseline -0.19 (95% CI -1.73, 1.35), P < 0.001], contrary to non-responders [follow-up -0.32 (95% CI -1.79, 1.14) versus baseline -0.72 (95% CI -2.19, 0.75), P = 0.381]. Conclusions: Clinical improvement of functional movement disorders after physiotherapy was associated with faster reaction times and normalization of CNV, which was absent at baseline. These findings suggest that CNV may constitute a useful neurophysiological biomarker related to abnormal attention in functional movement disorders.pt_PT
dc.description.sponsorshipThis study was supported by the Medical Research Council (UK). Glenn Nielsen and Mark J Edwards received research funding from the National Institute for Health Research. Simon Little was funded by a clinical research training grant from the Wellcome Trust (105804/Z/14/Z).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Neurol. 2020 Jun;27(6):985-994pt_PT
dc.identifier.doi10.1111/ene.14189pt_PT
dc.identifier.eissn1468-1331
dc.identifier.issn1351-5101
dc.identifier.urihttp://hdl.handle.net/10451/50424
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/14681331pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiomarkerspt_PT
dc.subjectFunctional neurological disorderspt_PT
dc.subjectFunctional movement disorderspt_PT
dc.subjectPsychogenic disorderspt_PT
dc.titleContingent negative variation: a biomarker of abnormal attention in functional movement disorderspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage994pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage985pt_PT
oaire.citation.titleEuropean Journal of Neurologypt_PT
oaire.citation.volume27pt_PT
person.familyNameTeodoro
person.familyNameFerreira
person.givenNameTiago
person.givenNameJoaquim J
person.identifier1624753
person.identifier.ciencia-id7D15-5CD6-6159
person.identifier.orcid0000-0003-4501-5532
person.identifier.orcid0000-0003-3950-5113
person.identifier.scopus-author-id7403252466
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf1495503-eaf6-43b5-8410-9da2ee7123ed
relation.isAuthorOfPublication54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9
relation.isAuthorOfPublication.latestForDiscovery54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9

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