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Gla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKD

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dc.contributor.authorSilva, Ana P.
dc.contributor.authorViegas, Carla S. B.
dc.contributor.authorGuilherme, Patrícia
dc.contributor.authorTavares, Nelson
dc.contributor.authorDias, Carolina
dc.contributor.authorRato, Fátima
dc.contributor.authorSantos, Nélio
dc.contributor.authorFaísca, Marília
dc.contributor.authorAlmeida, Edgar
dc.contributor.authorNeves, Pedro L.
dc.contributor.authorSimes, Dina C.
dc.date.accessioned2022-06-24T11:29:46Z
dc.date.available2022-06-24T11:29:46Z
dc.date.issued2022
dc.description© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractAccelerated and premature cardiovascular calcification is a hallmark of chronic kidney disease (CKD) patients. Valvular calcification (VC) is a critical indicator of cardiovascular disease and all-cause mortality in this population, lacking validated biomarkers for early diagnosis. Gla-rich protein (GRP) is a cardiovascular calcification inhibitor recently associated with vascular calcification, pulse pressure, mineral metabolism markers and kidney function. Here, we examined the association between GRP serum levels and mitral and aortic valves calcification in a cohort of 80 diabetic patients with CKD stages 2-4. Mitral and aortic valves calcification were detected in 36.2% and 34.4% of the patients and associated with lower GRP levels, even after adjustments for age and gender. In this pilot study, univariate, multivariate and Poisson regression analysis, show that low levels of GRP and magnesium (Mg), and high levels of phosphate (P) are associated with mitral and aortic valves calcification. Receiver operating characteristic (ROC) curves showed that the area under the curve (AUC) values of GRP for mitral (0.762) and aortic (0.802) valves calcification were higher than those of Mg and P. These results suggest that low levels of GRP and Mg, and high levels of P, are independent and cumulative risk factors for VC in this population; the GRP diagnostic value might be potentially useful in cardiovascular risk assessment.pt_PT
dc.description.sponsorshipThis research was funded by the Portuguese Society of Nephrology (SPN) through projects funding 2017 and 2019; by the Portuguese National Funds from FCT—Foundation for Science and Technology, through the transitional provision DL57/2016/CP1361/CT0006, and projects EXPL/BTM-TEC/0990/2021 and UIDB/04326/2020; and by AAC nº 41/ALG/2020—Project nº 072583—NUTRISAFE.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDiagnostics (Basel). 2022 Feb 15;12(2):496pt_PT
dc.identifier.doi10.3390/diagnostics12020496pt_PT
dc.identifier.eissn2075-4418
dc.identifier.urihttp://hdl.handle.net/10451/53477
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationDL57/2016/CP1361/CT0006pt_PT
dc.relationAlgarve Centre for Marine Sciences
dc.relation.publisherversionhttps://www.mdpi.com/journal/diagnosticspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGla-rich proteinpt_PT
dc.subjectCardiovascular calcificationpt_PT
dc.subjectCardiovascular diseasept_PT
dc.subjectCardiovascular risk assessmentpt_PT
dc.subjectChronic kidney diseasept_PT
dc.subjectValvular calcificationpt_PT
dc.subjectVascular calcificationpt_PT
dc.titleGla-rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in diabetic patients with moderate CKDpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberEXPL/BTM-TEC/0990/2021
oaire.awardNumberUIDB/04326/2020
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FBTM-TEC%2F0990%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.titleDiagnosticspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFernandes de Almeida
person.givenNameEdgar Avito
person.identifier.ciencia-id4910-CDF1-B27A
person.identifier.orcid0000-0003-0702-4569
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication24a175d4-d3d9-49a0-8668-364358714e76
relation.isAuthorOfPublication.latestForDiscovery24a175d4-d3d9-49a0-8668-364358714e76
relation.isProjectOfPublicationbf4924ac-68b0-4ac6-8754-c97cd3067423
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