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Off-label use of maraviroc in HIV-1-infected paediatric patients in clinical practice

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dc.contributor.authorPalladino, Claudia
dc.contributor.authorGómez, María Luisa Navarro
dc.contributor.authorSoler-Palacín, Pere
dc.contributor.authorGonzález-Tomé, María Isabel
dc.contributor.authorDe Ory, Santiago J.
dc.contributor.authorEspiau, María
dc.contributor.authorHoyos, Santiago Pérez
dc.contributor.authorLeón-Leal, Juan Antonio
dc.contributor.authorMéndez, María
dc.contributor.authorMoreno-Pérez, David
dc.contributor.authorGuasch, Claudia Fortuny
dc.contributor.authorSierra, Antoni Mur
dc.contributor.authorGuruceta, Itziar Pocheville
dc.contributor.authorGuillén, Santiago Moreno
dc.contributor.authorBriz, Verónica
dc.contributor.authorCoRISpe Working Group
dc.date.accessioned2024-01-24T19:37:44Z
dc.date.available2024-01-24T19:37:44Z
dc.date.issued2015
dc.date.updated2023-02-09T15:15:49Z
dc.descriptionCopyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.pt_PT
dc.description.abstractMaraviroc (MVC) is not approved for HIV-1-infected paediatric patients. This is the first assessment of the use of MVC-based salvage therapy in vertically HIV-1-infected paediatric patients in clinical settings. The results suggest that MVC-based salvage therapy is useful in children and adolescents with extensive resistance profile leading to maintained virological suppression in up to 88% of the patients with CCR5-tropic virus. The likelihood of treatment success might increase when MVC is combined with other active drugs.pt_PT
dc.description.sponsorshipFinancial support was received from Instituto de Salud Carlos III through the Red Temática de Investigación Cooperativa en Sida (ISCIII-RETIC RD06/006) and by grants from Instituto de Salud Carlos III (grant number: MPY 1039/14 to V.B.], FIPSE (grant number: 36-0910-10) and RIS (grant number: RD12/0017/0035 y RD12/0017/0037). C.P. is supported by the Portuguese Fundação para a Ciência e Tecnologia (FCT) (grant number SFRH/BPD/77448/2011). V.B. is supported by the Miguel Servet programme from Fondo de Investigación Sanitaria (ISCIII) (grant number CP13/00098).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPalladino C, Gómez MLN, Soler-Palacín P, González-Tomé MI, De Ory SJ, Espiau M, et al. Off-label use of maraviroc in HIV-1-infected paediatric patients in clinical practice. AIDS [Internet]. 23 de outubro de 2015;29(16):2155–9. Disponível em: https://journals.lww.com/00002030-201510230-00015pt_PT
dc.identifier.doi10.1097/QAD.0000000000000819pt_PT
dc.identifier.eid2-s2.0-84964904223
dc.identifier.slugcv-prod-1185529
dc.identifier.urihttp://hdl.handle.net/10451/62088
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer Healthpt_PT
dc.relationEPIDEMIOLOGY, PATHOGENESIS AND DETERMINANTS OF HIV-1 TRANSMISSION AND DISEASE PROGRESSION IN THE ANGOLAN PERINATAL HIV COHORT APEHC
dc.relation.publisherversionhttps://journals.lww.com/aidsonline/fulltext/2015/10230/off_label_use_of_maraviroc_in_hiv_1_infected.15.aspxpt_PT
dc.subjectadolescentspt_PT
dc.subjectchildrenpt_PT
dc.subjectHAARTpt_PT
dc.subjectHIV-1pt_PT
dc.subjectmaravirocpt_PT
dc.titleOff-label use of maraviroc in HIV-1-infected paediatric patients in clinical practicept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BPD/77448/2011
oaire.awardTitleEPIDEMIOLOGY, PATHOGENESIS AND DETERMINANTS OF HIV-1 TRANSMISSION AND DISEASE PROGRESSION IN THE ANGOLAN PERINATAL HIV COHORT APEHC
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F77448%2F2011/PT
oaire.citation.endPage2159pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage2155pt_PT
oaire.citation.titleAIDSpt_PT
oaire.citation.volume29pt_PT
oaire.fundingStreamOE
person.familyNamePalladino
person.givenNameClaudia
person.identifier.ciencia-id721D-6851-20D5
person.identifier.orcid0000-0002-8148-0928
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid721D-6851-20D5 | Claudia Palladino
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication96b2385b-89f4-428a-9ab2-6fdb5514541b
relation.isAuthorOfPublication.latestForDiscovery96b2385b-89f4-428a-9ab2-6fdb5514541b
relation.isProjectOfPublication5c32faa6-8a9f-4fd4-b3a7-fa871a159d96
relation.isProjectOfPublication.latestForDiscovery5c32faa6-8a9f-4fd4-b3a7-fa871a159d96

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FF - CiênciaVitae - Faculdade de Farmácia