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The effect of frailty on the relationship between cognition and depression symptoms in older people: a differential analysis by European regions

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dc.contributor.authorde Maio Nascimento, Marcelo
dc.contributor.authorIhle, Andreas
dc.contributor.authorGouveia, Elvio
dc.contributor.authorGonzalez, Ricardo Hugo
dc.contributor.authorMarques, Adilson
dc.date.accessioned2025-01-21T14:26:47Z
dc.date.available2025-01-21T14:26:47Z
dc.date.issued2025
dc.description© The Author(s), under exclusive licence to American Aging Association.pt_PT
dc.description.abstractThis study aimed to investigate the moderating effect of frailty on the relationship between cognition and symptoms of depression in individuals aged ≥65 and to explore differences between four European regions (West, North, South, and East). A cross-sectional analysis was conducted with 29,094 participants (16,365 women) from 27 countries, aged ≥65 years, who responded to wave 8 of the SHARE project. The variables analysed were depression (12-item EURO-D scale), frailty, and a general cognition index (CogId). A higher CogId was associated with less depression. Western and Northern European countries indicated better cognitive performance, lower depression symptomology, and frailty scores than those in the South and East. A pre-frail and frail status was a significant moderator, increasing the association between depression and cognition in the East, South, North, and West regions, respectively. The interaction effects between CogId and frailty were found in the West and East regions. Comparatively, the moderating role of frailty in countries in the Western region differed significantly from those in the North. In turn, countries in the South and East differed from those in the North region. Frailty was a moderator of depression symptoms, increasing its association with cognition. Strategies to prevent frailty are important to reduce the burden of depression and cognitive deficits in Europe.pt_PT
dc.description.sponsorshipThis paper uses data from SHARE Waves 7 (DOIs: 10.6103/SHARE.w7.700, 10.6103/SHARE.w8.100); see Börsch-Supan et al. [12] for methodological details. The SHARE data collection has been primarily funded by the European Commission through FP5 (QLK6-CT-2001-00360), FP6 (SHARE-I3: RII-CT-2006-062193, COMPARE: CIT5-CT2005-028857, SHARELIFE: CIT4-CT-2006-028812) and FP7 (SHARE-PREP: N°211909, SHARE-LEAP: N°227822, SHARE M4: N°261982). Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute on Aging (U01_AG09740-13S2, P01_AG005842, P01_AG08291, P30_AG12815, R21_AG025169, Y1-AG-4553-01, IAG_BSR06-11, OGHA_04-064, HHSN271201300071C) and from various national funding sources is gratefully acknowledged (see http://www.share-project.org/).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGeroscience. 2025 Jan 3pt_PT
dc.identifier.doi10.1007/s11357-024-01469-6pt_PT
dc.identifier.eissn2509-2723
dc.identifier.issn2509-2715
dc.identifier.urihttp://hdl.handle.net/10400.5/97420
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationQLK6-CT-2001-00360pt_PT
dc.relationRII-CT-2006-062193pt_PT
dc.relationCIT5-CT2005-028857pt_PT
dc.relationCIT4-CT-2006-028812pt_PT
dc.relationUpgrading the Survey of Health, Ageing and Retirement in Europe – preparatory phase
dc.relationLongitudinal Enhancement and Access imProvement of the SHARE infrastructure
dc.relationMultinational Advancement of Research Infrastructures on Ageing
dc.relation.publisherversionhttps://link.springer.com/journal/11357pt_PT
dc.subjectAgeingpt_PT
dc.subjectCognitionpt_PT
dc.subjectDepressionpt_PT
dc.subjectEuropept_PT
dc.subjectPhysical frailtypt_PT
dc.titleThe effect of frailty on the relationship between cognition and depression symptoms in older people: a differential analysis by European regionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumber211909
oaire.awardNumber227822
oaire.awardNumber261982
oaire.awardTitleUpgrading the Survey of Health, Ageing and Retirement in Europe – preparatory phase
oaire.awardTitleLongitudinal Enhancement and Access imProvement of the SHARE infrastructure
oaire.awardTitleMultinational Advancement of Research Infrastructures on Ageing
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/211909/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/227822/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/261982/EU
oaire.citation.titleGeroSciencept_PT
oaire.fundingStreamFP7
oaire.fundingStreamFP7
oaire.fundingStreamFP7
person.familyNameGouveia
person.familyNameMarques
person.givenNameElvio
person.givenNameAdilson
person.identifier.ciencia-id3B10-8BDF-0D67
person.identifier.ciencia-id5F18-F9C3-11CB
person.identifier.orcid0000-0003-0927-692X
person.identifier.orcid0000-0001-9850-7771
person.identifier.ridF-9156-2015
person.identifier.ridK-4529-2014
person.identifier.scopus-author-id36637395800
person.identifier.scopus-author-id55082567000
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication54a5bf32-51cd-4e5a-b56a-d242a214a958
relation.isAuthorOfPublication1971699a-ff03-48f6-92b9-6a3d7bce1111
relation.isAuthorOfPublication.latestForDiscovery1971699a-ff03-48f6-92b9-6a3d7bce1111
relation.isProjectOfPublication32d20a91-f76e-4c0b-8d5a-3739322f9966
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