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Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia

2020Artigo científico Acesso aberto
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dc.contributor.authorTsvetanov, Kamen A.
dc.contributor.authorGazzina, Stefano
dc.contributor.authorJones, P. Simon
dc.contributor.authorSwieten, John
dc.contributor.authorBorroni, Barbara
dc.contributor.authorSanchez‐Valle, Raquel
dc.contributor.authorMoreno, Fermin
dc.contributor.authorLaforce, Robert
dc.contributor.authorGraff, Caroline
dc.contributor.authorSynofzik, Matthis
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorMoore, Katrina M
dc.contributor.authorDuro, Diana
dc.contributor.authorFenoglio, Chiara
dc.contributor.authorFerrari, Camilla
dc.contributor.authorFerreira, Carlos
dc.contributor.authorFerreira, Catarina B.
dc.contributor.authorFlanagan, Toby
dc.contributor.authorFox, Nick
dc.contributor.authorFreedman, Morris
dc.contributor.authorFumagalli, Giorgio
dc.contributor.authorPanman, Jessica
dc.contributor.authorGabilondo, Alazne
dc.contributor.authorGasparotti, Roberto
dc.contributor.authorGauthier, Serge
dc.contributor.authorGazzina, Stefano
dc.contributor.authorGiaccone, Giorgio
dc.contributor.authorGorostidi, Ana
dc.contributor.authorGreaves, Caroline
dc.contributor.authorGuerreiro, Rita
dc.contributor.authorHeller, Carolin
dc.contributor.authorHoegen, Tobias
dc.contributor.authorPapma, Janne
dc.contributor.authorIndakoetxea, Begoña
dc.contributor.authorJelic, Vesna
dc.contributor.authorJiskoot, Lize
dc.contributor.authorKarnath, Hans‐Otto
dc.contributor.authorInstitutet, Karolinska
dc.contributor.authorKeren, Ron
dc.contributor.authorLangheinrich, Tobias
dc.contributor.authorLeitão, Maria João
dc.contributor.authorLladó, Albert
dc.contributor.authorLombardi, Gemma
dc.contributor.authorPiaceri, Irene
dc.contributor.authorLoosli, Sandra
dc.contributor.authorMaruta, Carolina
dc.contributor.authorMead, Simon
dc.contributor.authorMeeter, Lieke
dc.contributor.authorMiltenberger-Miltenyi, Gabriel
dc.contributor.authorvan Minkelen, Rick
dc.contributor.authorMitchell, Sara
dc.contributor.authorNacmias, Benedetta
dc.contributor.authorNeason, Mollie
dc.contributor.authorNicholas, Jennifer
dc.contributor.authorPievani, Michela
dc.contributor.authorOlives, Jaume
dc.contributor.authorPadovani, Alessandro
dc.contributor.authorPijnenburg, Yolande
dc.contributor.authorPolito, Cristina
dc.contributor.authorPremi, Enrico
dc.contributor.authorPrioni, Sara
dc.contributor.authorPrix, Catharina
dc.contributor.authorRademakers, Rosa
dc.contributor.authorMasellis, Mario
dc.contributor.authorRedaelli, Veronica
dc.contributor.authorRittman, Tim
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorRosa‐Neto, Pedro
dc.contributor.authorRossi, Giacomina
dc.contributor.authorRossor, Martin
dc.contributor.authorSantiago, Beatriz
dc.contributor.authorScarpini, Elio
dc.contributor.authorSchönecker, Sonja
dc.contributor.authorSemler, Elisa
dc.contributor.authorTartaglia, Maria Carmela
dc.contributor.authorShafei, Rachelle
dc.contributor.authorShoesmith, Christen
dc.contributor.authorTábuas‐Pereira, Miguel
dc.contributor.authorTainta, Mikel
dc.contributor.authorTaipa, Ricardo
dc.contributor.authorTang‐Wai, David
dc.contributor.authorThomas, David L
dc.contributor.authorThompson, Paul
dc.contributor.authorThonberg, Hakan
dc.contributor.authorTimberlake, Carolyn
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorTiraboschi, Pietro
dc.contributor.authorVandamme, Philip
dc.contributor.authorVandenbulcke, Mathieu
dc.contributor.authorVeldsman, Michele
dc.contributor.authorVerdelho, Ana
dc.contributor.authorVillanua, Jorge
dc.contributor.authorWarren, Jason
dc.contributor.authorWilke, Carlo
dc.contributor.authorWoollacott, Ione
dc.contributor.authorWlasich, Elisabeth
dc.contributor.authorVandenberghe, Rik
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorZulaica, Miren
dc.contributor.authorDe Mendonça, Alexandre
dc.contributor.authorTagliavini, Fabrizio
dc.contributor.authorSantana, Isabel
dc.contributor.authorDucharme, Simon
dc.contributor.authorButler, Chris
dc.contributor.authorGerhard, Alexander
dc.contributor.authorDanek, Adrian
dc.contributor.authorLevin, Johannes
dc.contributor.authorOtto, Markus
dc.contributor.authorFrisoni, Giovanni
dc.contributor.authorGhidoni, Roberta
dc.contributor.authorSorbi, Sandro
dc.contributor.authorRohrer, Jonathan D.
dc.contributor.authorRowe, James B.
dc.contributor.authorAfonso, Sónia
dc.contributor.authorAlmeida, Maria Rosario
dc.contributor.authorAnderl‐Straub, Sarah
dc.contributor.authorAndersson, Christin
dc.contributor.authorAntonell, Anna
dc.contributor.authorArchetti, Silvana
dc.contributor.authorArighi, Andrea
dc.contributor.authorBalasa, Mircea
dc.contributor.authorBarandiaran, Myriam
dc.contributor.authorBargalló, Nuria
dc.contributor.authorBartha, Robart
dc.contributor.authorBender, Benjamin
dc.contributor.authorBenussi, Luisa
dc.contributor.authorBessi, Valentina
dc.contributor.authorBinetti, Giuliano
dc.contributor.authorBlack, Sandra
dc.contributor.authorBocchetta, Martina
dc.contributor.authorBorrego‐Ecija, Sergi
dc.contributor.authorBras, Jose
dc.contributor.authorBruffaerts, Rose
dc.contributor.authorCaroppo, Paola
dc.contributor.authorCash, David
dc.contributor.authorCastelo-Branco, Miguel
dc.contributor.authorConvery, Rhian
dc.contributor.authorCope, Thomas
dc.contributor.authorCosseddu, Maura
dc.contributor.authorde Arriba, María
dc.contributor.authorDi Fede, Giuseppe
dc.contributor.authorDíaz, Zigor
dc.date.accessioned2021-04-06T16:59:34Z
dc.date.available2021-04-06T16:59:34Z
dc.date.issued2020
dc.description© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractIntroduction: The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial frontotemporal dementia (FTD). Methods: We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data-driven approach to link cognitive performance with both structural and functional magnetic resonance imaging. Atrophy and brain network connectivity were compared between groups, in relation to the time from expected symptom onset. Results: There were group differences in brain structure and function, in the absence of differences in cognitive performance. Specifically, we identified behaviorally relevant structural and functional network differences. Structure-function relationships were similar in both groups, but coupling between functional connectivity and cognition was stronger for carriers than for non-carriers, and increased with proximity to the expected onset of disease. Discussion: Our findings suggest that the maintenance of functional network connectivity enables carriers to maintain cognitive performance.pt_PT
dc.description.sponsorshipK.A.T. is supported by the British Academy Postdoctoral Fellowship (PF160048) and the Guarantors of Brain (101149). J.B.R. is supported by the Wellcome Trust (103838), the Medical Research Council (SUAG/051 G101400), and the Cambridge NIHR Biomedical Research Centre. R. S.‐V. is supported by the Instituto de Salud Carlos III and the JPND network PreFrontAls (01ED1512/AC14/0013) and the Fundació Marató de TV3 (20143810). M.M and E.F are supported by the UK Medical Research Council, the Italian Ministry of Health, and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, and also a Canadian Institutes of Health Research operating grant (MOP 327387) and funding from the Weston Brain Institute. J.D.R., D.C., and K.M.M. are supported by the NIHR Queen Square Dementia Biomedical Research Unit, the NIHR UCL/H Biomedical Research Centre, and the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility. J.D.R. is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH), the MRC UK GENFI grant (MR/ M023664/1), and The Bluefield Project. F.T. is supported by the Italian Ministry of Health (Grant NET‐2011‐02346784). L.C.J. and J.V.S. are supported by the Association for Frontotemporal Dementias Research Grant 2009, ZonMw Memorabel project number 733050103 and 733050813, and the Bluefield project. R.G. is supported by Italian Ministry of Health, Ricerca Corrente. J.L. was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145; SyNergy ‐ ID 390857198). The Swedish contributors C.G., L.O., and C.A. were supported by grants from JPND Prefrontals Swedish Research Council (VR) 529‐2014‐7504, JPND GENFI‐PROX Swedish Research Council (VR) 2019‐02248, Swedish Research Council (VR) 2015‐ 02926, Swedish Research Council (VR) 2018‐02754, Swedish FTD Initiative‐Schorling Foundation, Swedish Brain Foundation, Swedish Alzheimer Foundation, Stockholm County Council ALF, Karolinska Institutet Doctoral Funding, and StratNeuro, Swedish Demensfonden, during the conduct of the study.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlzheimers Dement. 2021 Mar;17(3):500-514pt_PT
dc.identifier.doi10.1002/alz.12209pt_PT
dc.identifier.eissn1552-5279
dc.identifier.issn1552-5260
dc.identifier.urihttp://hdl.handle.net/10451/47260
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Inc.pt_PT
dc.relation.publisherversionhttps://alz-journals.onlinelibrary.wiley.com/journal/15525279pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFrontotemporal dementia (FTD)pt_PT
dc.subjectFunctional magnetic resonance imaging (fMRI)pt_PT
dc.subjectNetwork connectivitypt_PT
dc.subjectPresymptomaticpt_PT
dc.titleBrain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage514pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage500pt_PT
oaire.citation.titleAlzheimer's & Dementiapt_PT
oaire.citation.volume17pt_PT
person.familyNameMaruta
person.familyNameMiltenberger-Miltenyi
person.familyNameVerdelho
person.familyNamede Mendonça
person.familyNameCastelo-Branco
person.givenNameCarolina
person.givenNameGabriel
person.givenNameAna
person.givenNameAlexandre
person.givenNameMiguel
person.identifier351267
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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