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Cerageninas: novos agentes antimicrobianos derivados de esteróides
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Orientador(es)
Resumo(s)
O objetivo do presente trabalho é elucidar para a importância de novos agentes
antimicrobianos, nomeadamente das cerageninas, no combate aos microorganismos
resistentes aos antibióticos atualmente disponíveis. Este é um papel cada vez mais importante
nos dias de hoje, pois os casos de resistências aos antibióticos estão a crescer cada vez mais
rápido. Assim é, crucial encontrar novos compostos e novas formas de evitar o
desenvolvimento de resistência.
As cerageninas são compostos derivados dos esteróides com atividade antimicrobiana,
que vão de forma sintética simular o mecanismo de ação dos péptidos antimicrobianos
existentes em vários organismos, mas que devido ao seu elevado custo e dificuldade de
produção em grande escala, não são utilizados como agentes antimicrobianos. Assim, para
colmatar essa dificuldade criaram-se as cerageninas e neste trabalho vamos analisar as suas
propriedades antimicrobianas, o seu mecanismo de ação, a sua estrutura química, o
desenvolvimento de possíveis resistências e as suas vantagens e desvantagens em comparação
com outros antibióticos existentes no mercado.
Estas têm atividade bactericida contra bactérias Gram-positivas e Gram-negativas,
sendo a CSA-13 a mais potente da classe das cerageninas. É de todo o interesse a realização
de mais estudos a nível in vivo para poder usar as potencialidades destes compostos, tal como
provado in vitro.
With the presented paper it is our purpose to demonstrate the importance of new antimicrobial agents, in particular ceragenins to help fight existing antibiotic resistances against several microorganisms present in our environment. This is an increasingly important matter nowadays since antibiotic resistance cases are growing faster every day. Therefore it is crucial to find new compounds and new ways of eliminating these resistances. The ceragenins are compounds made from steroids with antimicrobial activity that simulate synthetically the action mechanism of antimicrobial peptides existing in several organisms. But because they are expensive and difficult to produce in large scales, they are not used as antimicrobial agents. So, to overcome this matter, ceragenins were created. On this paper we will analyze ceragenins antimicrobial properties, its action mechanism, its chemical structure, the developments of possible resistances and its advantages and disadvantages, We will also compare its activity with other antibiotics in the market. Ceragenins have bactericidal activity against Gram-positive and Gram-negative bacteria. The ceragenin CSA-13 is the most powerful of them. It is of most interest the performance of more in vivo studies so we can use the full potential of these compounds, as they have already been proved in vitro.
With the presented paper it is our purpose to demonstrate the importance of new antimicrobial agents, in particular ceragenins to help fight existing antibiotic resistances against several microorganisms present in our environment. This is an increasingly important matter nowadays since antibiotic resistance cases are growing faster every day. Therefore it is crucial to find new compounds and new ways of eliminating these resistances. The ceragenins are compounds made from steroids with antimicrobial activity that simulate synthetically the action mechanism of antimicrobial peptides existing in several organisms. But because they are expensive and difficult to produce in large scales, they are not used as antimicrobial agents. So, to overcome this matter, ceragenins were created. On this paper we will analyze ceragenins antimicrobial properties, its action mechanism, its chemical structure, the developments of possible resistances and its advantages and disadvantages, We will also compare its activity with other antibiotics in the market. Ceragenins have bactericidal activity against Gram-positive and Gram-negative bacteria. The ceragenin CSA-13 is the most powerful of them. It is of most interest the performance of more in vivo studies so we can use the full potential of these compounds, as they have already been proved in vitro.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014
Palavras-chave
Cerageninas Péptidos antimicrobianos Atividade antimicrobiana