Publicação
Progressive long-term synaptic depression at cortical inputs into the amygdala
| dc.contributor.author | Psyrakis, Dimitrios | |
| dc.contributor.author | Jasiewicz, Julia | |
| dc.contributor.author | Wehrmeister, Michael | |
| dc.contributor.author | Bonni, Kathrin | |
| dc.contributor.author | Lutz, Beat | |
| dc.contributor.author | Kodirov, Sodikdjon | |
| dc.date.accessioned | 2024-11-19T15:44:42Z | |
| dc.date.available | 2024-11-19T15:44:42Z | |
| dc.date.issued | 2024 | |
| dc.description | © 2024 International Brain Research Organization (IBRO). Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies | pt_PT |
| dc.description.abstract | The convergence of conditioned and unconditioned stimuli (CS and US) into the lateral amygdala (LA) serves as a substrate for an adequate fear response in vivo. This well-known Pavlovian paradigm modulates the synaptic plasticity of neurons, as can be proved by the long-term potentiation (LTP) phenomenon in vitro. Although there is an increasing body of evidence for the existence of LTP in the amygdala, only a few studies were able to show a reliable long-term depression (LTD) of excitation in this structure. We have used coronal brain slices and conducted patch-clamp recordings in pyramidal neurons of the lateral amygdala (LA). After obtaining a stable baseline excitatory postsynaptic current (EPSC) response at a holding potential of -70 mV, we employed a paired-pulse paradigm at 1 Hz at the same membrane potential and could observe a reliable LTD. The different durations of stimulation (ranging between 1.5-24 min) were tested first in the same neuron, but the intensity was kept constant. The latter paradigm resulted in a step-wise LTD with a gradually increasing magnitude under these conditions. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Neuroscience. 2024 Sep 25:556:52-65 | pt_PT |
| dc.identifier.doi | 10.1016/j.neuroscience.2024.07.049 | pt_PT |
| dc.identifier.eissn | 1873-7544 | |
| dc.identifier.issn | 0306-4522 | |
| dc.identifier.uri | http://hdl.handle.net/10400.5/95444 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | https://www.sciencedirect.com/journal/neuroscience | pt_PT |
| dc.subject | Action potential | pt_PT |
| dc.subject | Fear circuit | pt_PT |
| dc.subject | Long-term synaptic plasticity | pt_PT |
| dc.subject | Patch-clamp | pt_PT |
| dc.subject | Spike | pt_PT |
| dc.title | Progressive long-term synaptic depression at cortical inputs into the amygdala | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 65 | pt_PT |
| oaire.citation.startPage | 52 | pt_PT |
| oaire.citation.title | Neuroscience | pt_PT |
| oaire.citation.volume | 556 | pt_PT |
| person.familyName | Kodirov | |
| person.givenName | Sodikdjon | |
| person.identifier.orcid | 0000-0002-7712-6037 | |
| person.identifier.scopus-author-id | 6602928416 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | c7f8b3a7-8236-4133-8870-d59a7ab71169 | |
| relation.isAuthorOfPublication.latestForDiscovery | c7f8b3a7-8236-4133-8870-d59a7ab71169 |