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Characteristics of starch-based pellets produced by hot-melt extrusion

2014Master thesis Restricted access
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datacite.subject.fosCiências da Saúdept_PT
dc.contributor.advisorPinto, João
dc.contributor.advisorRein, Hubert
dc.contributor.authorSoares, Felipa Diaz-Argüelles y
dc.date.accessioned2019-08-02T15:50:37Z
dc.date.available2019-08-02T15:50:37Z
dc.date.issued2014
dc.date.submitted2014
dc.descriptionTrabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014pt_PT
dc.description.abstractStarch is a polymer that enables the production of pellets by hot-melt extrusion with stable characteristics. Pellets with different types and percentages of starch (common corn starch, waxy corn starch and amylon corn starch), sucrose and acetaminophen were obtained. After production some parameters were measured, such as pellet’s size distribution, shape, density, specific surface area and porosity, in order to evaluate the influence of each formulation on the pellets’ characteristics and which formulation showed better qualities for controlled release of a drug. All the formulations presented stable characteristics and an uniform size distribution. Even though further studies would be essential to obtain reliable results about controlled drug release, pellets containing amylon corn starch proved to have the most suitable characteristics, while waxy corn starch would be more suitable if a faster release was intended.pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/39271
dc.language.isoengpt_PT
dc.subjectStarchpt_PT
dc.subjectPelletspt_PT
dc.subjectAcetaminophenpt_PT
dc.subjectHot-melt extrusionpt_PT
dc.subjectDrug releasept_PT
dc.subjectMestrado Integrado - 2014pt_PT
dc.titleCharacteristics of starch-based pellets produced by hot-melt extrusionpt_PT
dc.typemaster thesis
dspace.entity.typePublication
rcaap.rightsrestrictedAccesspt_PT
rcaap.typemasterThesispt_PT
thesis.degree.nameMestrado Integrado em Ciências Farmacêuticaspt_PT

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