Seronegative infection and AIDS caused by an A2 subsubtype HIV-1

Cardoso, Ana Rita; Gonçalves, Cristina; Pascoalinho, Dulce; Gil, Catarina; Ferreira, António Fernandes; Bártolo, Inês; Taveira, Nuno

http://hdl.handle.net/10400.5/102927

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Authors

Ferreira, António Fernandes

Bártolo, Inês

Taveira, Nuno

Abstract(s)

The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with an A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.

Description

This work was supported by grant CRIA-CR3751 from Comissão Nacional de Luta Contra a SIDA, Portugal.

URI

http://hdl.handle.net/10400.5/102927

Citation

Cardoso AR, Gonçalves C, Pascoalinho D, Gil C, Ferreira AF, Bártolo I, Taveira N. Seronegative infection and AIDS caused by an A2 subsubtype HIV-1: AIDS 2004;18:1071–4. https://doi.org/10.1097/00002030-200404300-00018.