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Methimazole associated eosinophilic pleural effusion: a case report

2017Journal article Open access
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dc.contributor.authorGaspar da Costa, Pedro
dc.contributor.authorDuarte Silva, Filipa
dc.contributor.authorHenriques, Júlia
dc.contributor.authorVale, Sónia do
dc.contributor.authorBraz, Sandra
dc.contributor.authorMeneses Santos, João
dc.contributor.authorM.M. Victorino, Rui
dc.date.accessioned2020-12-09T14:26:06Z
dc.date.available2020-12-09T14:26:06Z
dc.date.issued2017
dc.description© The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.pt_PT
dc.description.abstractBackground: Adverse reactions associated to anti-thyroid drugs include fever, rash, arthralgia, agranulocytosis and hepatitis that are thought to be hypersensitivity reactions. Five cases of pleural effusion associated to thionamides have also been reported, two with propylthiouracil and three with carbimazole. Case presentation: We report here a case of a 75-year-old man admitted because of unilateral pleural effusion. The patient had a recent diagnosis of hyperthyroidism and 6 days after starting methimazole complained of pleuritic chest pain. He had elevated C-reactive protein and erythrocyte sedimentation rate and normal white blood cell count and liver enzymes. Chest radiography showed a moderate right pleural effusion and the ultrasound revealed a loculated effusion that was shown to be an eosinophilic exudate. Conclusions: The temporal relationship between methimazole intake and the development of pleural effusion combined with the extensive exclusion of alternative causes, namely infectious, neoplastic and primary auto-immune diseases, led to the diagnosis of hypersensitivity reaction to methimazole. The thionamide was stopped and corticosteroid was started with complete resolution of the pleural effusion in 3 months. Awareness of this rare adverse reaction of anti-thyroid drugs is important and methimazole can be added to the list of possible etiologies of drug-induced eosinophilic pleural effusion.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBMC Pharmacol Toxicol. 2017 Mar 21;18(1):16pt_PT
dc.identifier.doi10.1186/s40360-017-0121-1pt_PT
dc.identifier.eissn2050-6511
dc.identifier.urihttp://hdl.handle.net/10451/45190
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Central Ltd.pt_PT
dc.relation.publisherversionhttps://bmcpharmacoltoxicol.biomedcentral.com/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEosinophilic pleural effusionpt_PT
dc.subjectThionamidespt_PT
dc.subjectMethimazolept_PT
dc.subjectHypersensitivity reactionpt_PT
dc.subjectCase reportpt_PT
dc.titleMethimazole associated eosinophilic pleural effusion: a case reportpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage16pt_PT
oaire.citation.titleBMC Pharmacology and Toxicologypt_PT
oaire.citation.volume18pt_PT
person.familyNamedo Vale
person.givenNameSónia
person.identifier282322
person.identifier.ciencia-id0E1A-AE02-05AB
person.identifier.orcid0000-0001-9287-4095
person.identifier.scopus-author-id15825086700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcff86a29-07ce-4454-8325-5774370286ff
relation.isAuthorOfPublication.latestForDiscoverycff86a29-07ce-4454-8325-5774370286ff

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