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Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group

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dc.contributor.authorChevalley, Thierry
dc.contributor.authorBrandi, Maria Luisa
dc.contributor.authorCashman, Kevin D.
dc.contributor.authorCavalier, Etienne
dc.contributor.authorHarvey, Nicholas C.
dc.contributor.authorMaggi, Stefania
dc.contributor.authorCooper, Cyrus
dc.contributor.authorAl-Daghri, Nasser
dc.contributor.authorBock, Oliver
dc.contributor.authorBruyère, Olivier
dc.contributor.authorRosa, Mário Miguel
dc.contributor.authorCortet, Bernard
dc.contributor.authorCruz-Jentoft, Alfonso J.
dc.contributor.authorCherubini, Antonio
dc.contributor.authorDawson-Hughes, Bess
dc.contributor.authorFielding, Roger
dc.contributor.authorFuggle, Nicholas
dc.contributor.authorHalbout, Philippe
dc.contributor.authorKanis, John A.
dc.contributor.authorKaufman, Jean-Marc
dc.contributor.authorLamy, Olivier
dc.contributor.authorLaslop, Andrea
dc.contributor.authorYerro, Maria Concepción Prieto
dc.contributor.authorRadermecker, Régis
dc.contributor.authorThiyagarajan, Jotheeswaran Amuthavalli
dc.contributor.authorThomas, Thierry
dc.contributor.authorVeronese, Nicola
dc.contributor.authorde Wit, Marten
dc.contributor.authorReginster, Jean-Yves
dc.contributor.authorRizzoli, René
dc.date.accessioned2023-04-21T14:07:24Z
dc.date.available2023-04-21T14:07:24Z
dc.date.issued2022
dc.description© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractVitamin D is a key component for optimal growth and for calcium-phosphate homeostasis. Skin photosynthesis is the main source of vitamin D. Limited sun exposure and insufficient dietary vitamin D supply justify vitamin D supplementation in certain age groups. In older adults, recommended doses for vitamin D supplementation vary between 200 and 2000 IU/day, to achieve a goal of circulating 25-hydroxyvitamin D (calcifediol) of at least 50 nmol/L. The target level depends on the population being supplemented, the assessed system, and the outcome. Several recent large randomized trials with oral vitamin D regimens varying between 2000 and 100,000 IU/month and mostly conducted in vitamin D-replete and healthy individuals have failed to detect any efficacy of these approaches for the prevention of fracture and falls. Considering the well-recognized major musculoskeletal disorders associated with severe vitamin D deficiency and taking into account a possible biphasic effects of vitamin D on fracture and fall risks, an European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group convened, carefully reviewed, and analyzed the meta-analyses of randomized controlled trials on the effects of vitamin D on fracture risk, falls or osteoarthritis, and came to the conclusion that 1000 IU daily should be recommended in patients at increased risk of vitamin D deficiency. The group also addressed the identification of patients possibly benefitting from a vitamin D loading dose to achieve early 25-hydroxyvitamin D therapeutic level or from calcifediol administration.pt_PT
dc.description.sponsorshipOpen access funding provided by University of Genevapt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAging Clin Exp Res. 2022 Nov;34(11):2603-2623pt_PT
dc.identifier.doi10.1007/s40520-022-02279-6pt_PT
dc.identifier.eissn1720-8319
dc.identifier.issn1594-0667
dc.identifier.urihttp://hdl.handle.net/10451/57228
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/40520pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFallspt_PT
dc.subjectFragility fracturept_PT
dc.subjectOsteoarthritispt_PT
dc.subjectVitamin Dpt_PT
dc.titleRole of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working grouppt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2623pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage2603pt_PT
oaire.citation.titleAging Clinical and Experimental Researchpt_PT
oaire.citation.volume34pt_PT
person.familyNameCOELHO DA SILVA ROSA
person.givenNameMÁRIO MIGUEL
person.identifier.ciencia-idAD12-9209-3302
person.identifier.orcid0000-0003-3158-2106
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7a1bfd39-f7e2-461d-9409-72b34b799ad7
relation.isAuthorOfPublication.latestForDiscovery7a1bfd39-f7e2-461d-9409-72b34b799ad7

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