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The giant miniature endplate potentials frequency is increased in aged rats

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dc.contributor.authorPousinha, Paula
dc.contributor.authorMarcal Correia, Alexandra
dc.contributor.authorSebastião, Ana M
dc.contributor.authorRibeiro, Joaquim A.
dc.date.accessioned2022-03-18T16:29:11Z
dc.date.available2022-03-18T16:29:11Z
dc.date.issued2015
dc.description© 2014 Elsevier Ireland Ltd. All rights reserved.pt_PT
dc.description.abstractAt the neuromuscular junction, spontaneous giant events (GMEPPs) are enhanced in different conditions when degenerative and/or remodeling processes take place, but no one investigated their incidence upon aging. In the present work, we evaluated evoked and spontaneous neuromuscular transmission events recorded from single muscle fibers. Phrenic-diaphragm preparations of 3-4, 12-16, 36-40 and 70-80 weeks old rat males were used. We found that the occurrence of GMEPPs significantly increases in aged rats. Moreover, in old rats the neuromuscular transmission was significantly impaired due to a significant decrease in the amplitude and quantal content of evoked endplate potentials. Interestingly, the number of observed EPPs failures were ∼ 3 times lower than the predicted value based on the quantal content. This discrepancy was not observed in infant or adult rats. The coincidence of a high GMEPPs frequency with a lower than expected EPPs failure rate suggests that GMEPPs events are needed to preserve effective neuromuscular transmission in aged animals.pt_PT
dc.description.sponsorshipThis work was supported by Fundação do Ministério da Ciência e Tecnologia de Portugal and European Union [Grant NEREPLAS, COST B30]. P.A.P. was the recipient of a Fundação do Ministério de Ciência e Tecnologia de Portugal fellowship [Grant SFRH/BD/28073/2006].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeurosci Lett. 2015 Jan 1;584:224-229pt_PT
dc.identifier.doi10.1016/j.neulet.2014.10.035pt_PT
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/10451/51832
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/neuroscience-letterspt_PT
dc.subjectAgingpt_PT
dc.subjectGMEPPspt_PT
dc.subjectNeuromuscular junctionpt_PT
dc.subjectNeuromuscular transmissionpt_PT
dc.titleThe giant miniature endplate potentials frequency is increased in aged ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/28073/2006
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F28073%2F2006/PT
oaire.citation.endPage229pt_PT
oaire.citation.startPage224pt_PT
oaire.citation.titleNeuroscience Letterspt_PT
oaire.citation.volume584pt_PT
oaire.fundingStreamSFRH
person.familyNamePousinha
person.familyNameMarcal Correia
person.familyNameSebastião
person.familyNameRibeiro
person.givenNamePaula
person.givenNameAlexandra
person.givenNameAna M
person.givenNameJoaquim
person.identifier.ciencia-id6E1A-99F3-5650
person.identifier.ciencia-id0E1C-4225-1F29
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.ciencia-id081F-2518-907F
person.identifier.orcid0000-0002-5992-9418
person.identifier.orcid0000-0002-4999-0477
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0002-9330-3507
person.identifier.ridW-8107-2018
person.identifier.scopus-author-id14037896300
person.identifier.scopus-author-id7103011044
person.identifier.scopus-author-id7004409879
person.identifier.scopus-author-id35498669400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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