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Multidrug Resistance Modulation and Apoptosis Induction of Cancer Cells by Terpenic Compounds Isolated from Euphorbia Species

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dc.contributor.authorDuarte, Noelia
dc.contributor.authorRamalhete, Catia
dc.contributor.authorVarga, Andras
dc.contributor.authorMolnar, Joseph
dc.contributor.authorFerreira, Maria-Jose U.
dc.date.accessioned2015-12-30T10:18:11Z
dc.date.available2015-12-30T10:18:11Z
dc.date.issued2009
dc.description.abstractBackground: One of the most promising strategies to overcome multidrug resistance (MDR) is to use compounds that can modulate P-glycoprotein and restore the cytotoxicity of anticancer drugs. Furthermore, the search for compounds that regulate and overcome apoptosis deficiency of cancer cells is also of great therapeutic importance. Materials and Methods: Seven known pentacyclic triterpenes and one steroid were isolated from Euphorbia lagascae methanolic extracts and identified by physical and spectroscopic methods. These compounds, together with eleven terpenoids previously isolated from Euphorbia lagascae and E. tuckeyana were tested for their MDR-reversing and/or apoptosis induction activities by flow cytometry on L5178 human MDR1 gene-transfected mouse lymphoma cells. Results: Four taraxastane-type triterpenes: 21 alpha-hydroxytaraxasterol, 21 alpha-hydroxytaraxasterol acetate, 3 beta,30-dihydroxy-20(21)-taraxastene and 3 beta-hydroxy-20-taraxasten-30-al, and two steroids: stigmastane-3,6-dione and ergosterol peroxide exhibited a significant MDR-Pgp modulation activity. Some aspects of structure-activity relationships are discussed. Regarding apoptosis induction, the most significant results were obtained for the polycyclic diterpenes ent-16 alpha, 17-dihydroxykauran-3-one and ent-16 alpha,17-dihydroxyatisan-3-one.
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dc.identifier.citationANTICANCER RESEARCH. - Vol. 29, n. 11 (NOV 2009), p. 4467-4472
dc.identifier.issn0250-7005
dc.identifier.urihttp://hdl.handle.net/10451/21456
dc.language.isoeng
dc.publisherINT INST ANTICANCER RESEARCH
dc.subjectOncology
dc.titleMultidrug Resistance Modulation and Apoptosis Induction of Cancer Cells by Terpenic Compounds Isolated from Euphorbia Species
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4472por
oaire.citation.startPage4467por
oaire.citation.titleANTICANCER RESEARCHpor
oaire.citation.volumeVol. 29por
rcaap.rightsrestrictedAccess
rcaap.typearticle

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