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Adjuvant antithrombotic therapy in ST-elevation myocardial infarction : contemporaneous portuguese cross-sectional data

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dc.contributor.authorCaldeira, Daniel
dc.contributor.authorPereira, Hélder
dc.contributor.authorMarques, Ana
dc.contributor.authorAlegria, Sofia
dc.contributor.authorCalisto, João
dc.contributor.authorCanas da Silva, Pedro
dc.contributor.authorRibeiro, Vasco Gama
dc.contributor.authorSilva, João Carlos
dc.contributor.authorSeixo, Filipe
dc.contributor.authorAbreu, Pedro Farto e
dc.contributor.authorTeles, Rui Campante
dc.contributor.authorFernandes, Renato
dc.contributor.authorCarvalho, Henrique Cyrne
dc.date.accessioned2020-06-18T10:50:10Z
dc.date.available2020-06-18T10:50:10Z
dc.date.issued2019
dc.description© 2020 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L.U. This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).pt_PT
dc.description.abstractIntroduction: The standard of care for acute ST-elevation myocardial infarction (STEMI) includes the activation of a STEMI care network, the administration of adjuvant medical therapy, and reperfusion through primary percutaneous coronary intervention (PCI). While primary PCI is nowadays the first option for the treatment of patients with STEMI, antithrombotic therapy, including antiplatelet and anticoagulant agents, is the cornerstone of pharmacological treatment to optimize their clinical outcomes. Objective: The aim of this study was to describe contemporaneous real-world patterns of use of antithrombotic treatments in Portugal for STEMI patients undergoing primary PCI. Methods: An observational, retrospective cross-sectional study was performed for the year 2016, based on data from two national registries: the Portuguese Registry on Acute Coronary Syndromes (ProACS) and the Portuguese Registry on Interventional Cardiology (PRIC). Data on oral antiplatelet and procedural intravenous antithrombotic drugs were retrieved. Results: In 2016, the ProACS enrolled 534 STEMI patients treated with primary PCI, while the PRIC registry reported data on 2625 STEMI patients. Of these, 99.6% were treated with aspirin and 75.6% with dual antiplatelet therapy (mostly clopidogrel). GP IIb/IIIa inhibitors (mostly abciximab) were used in 11.6% of cases. Heparins were used in 80% of cases (78% unfractionated heparin [UFH] and 2% low molecular weight heparin). None of the patients included in the registry were treated with cangrelor, prasugrel or bivalirudin. Missing data are one of the main limitations of the registries. Conclusions: In 2016, according to data from these national registries, almost all patients with STEMI were treated with aspirin and 76% with dual antiplatelet agents, mostly clopidogrel. GP IIb/IIIa inhibitors were used in few patients, and UFH was the most prevalent parenteral anticoagulant drug.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRev Port Cardiol. 2019; 38 (11): 809-814pt_PT
dc.identifier.doi10.1016/j.repc.2019.02.015pt_PT
dc.identifier.eissn2174-2030
dc.identifier.issn0870-2551
dc.identifier.urihttp://hdl.handle.net/10451/43858
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/revista-portuguesa-de-cardiologiapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMyocardial infarctionpt_PT
dc.subjectAntiplateletpt_PT
dc.subjectAnticoagulantpt_PT
dc.subjectAntithromboticpt_PT
dc.subjectAdjuvantpt_PT
dc.titleAdjuvant antithrombotic therapy in ST-elevation myocardial infarction : contemporaneous portuguese cross-sectional datapt_PT
dc.title.alternativeTerapêutica antitrombótica adjuvante no enfarte do miocárdio com elevação do segment ST : dados portugueses transversais contemporâneospt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage814pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage809pt_PT
oaire.citation.titleRevista Portuguesa de Cardiologíapt_PT
oaire.citation.volume38pt_PT
person.familyNameCaldeira
person.familyNameCanas da Silva
person.givenNameDaniel
person.givenNamePedro
person.identifier.ciencia-idAA19-EC35-8D01
person.identifier.orcid0000-0002-2520-5673
person.identifier.orcid0000-0002-7338-8582
person.identifier.scopus-author-id36623384200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationeba36bb8-5eb3-4ccc-88f8-bd7012d42382
relation.isAuthorOfPublication255f93bf-eba8-416b-ab4f-d8c86f848ccd
relation.isAuthorOfPublication.latestForDiscovery255f93bf-eba8-416b-ab4f-d8c86f848ccd

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