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Association of Isotretinoin with depression and suicide: a review of current literature

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dc.contributor.authorOliveira, João Miguel
dc.contributor.authorSobreira, Gonçalo
dc.contributor.authorVelosa, Jorge
dc.contributor.authorTelles Correia, Diogo
dc.contributor.authorFilipe, Paulo
dc.date.accessioned2020-10-28T09:45:10Z
dc.date.available2020-10-28T09:45:10Z
dc.date.issued2017
dc.descriptionCopyright © 2020 by Canadian Dermatology Association.pt_PT
dc.description.abstractAcne vulgaris, a condition that can affect people at any age, is the most common cause of referral to a dermatologist. Isotretinoin (ITT) is the most effective treatment available, but serious adverse effects, including a possible association with depression and suicide, limit its use. We review the current literature regarding the association of ITT with depression and suicide. Case reports and database studies show a clear association, and this association is biologically plausible. Although prospective studies have opposite results, limitations make them unsuitable to identify a subgroup of patients who may be at risk of developing depression or suicidal ideation with ITT. Overall, it seems some people might be at risk, particularly those with a personal or family history of mental disorder, but further studies are needed to identify those patients who would benefit from an early referral to a mental health professional when ITT is initiated. Currently, no conclusions can be drawn, and it seems appropriate to regularly screen all patients on ITT for depressive symptoms and suicidal ideation and promptly refer them to a mental health professional if any are found.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira JM, Sobreira G, Velosa J, Telles Correia D, Filipe P. Association of Isotretinoin With Depression and Suicide: A Review of Current Literature. Journal of Cutaneous Medicine and Surgery. 2018;22(1):58-64pt_PT
dc.identifier.doi10.1177/1203475417719052pt_PT
dc.identifier.issn1615-7109
dc.identifier.urihttp://hdl.handle.net/10451/44674
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSage Journalspt_PT
dc.relationThe author(s) received no financial support for the research, authorship, and/or publication of this article.pt_PT
dc.relation.publisherversionhttps://journals.sagepub.com/doi/10.1177/1203475417719052pt_PT
dc.subjectIsotretinoinpt_PT
dc.subjectAcne vulgarispt_PT
dc.subjectDepressionpt_PT
dc.subjectSuicidept_PT
dc.titleAssociation of Isotretinoin with depression and suicide: a review of current literaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage64pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage58pt_PT
oaire.citation.titleJournal of Cutaneous Medicine and Surgerypt_PT
oaire.citation.volume22pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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