Emerging biomarkers and targeted therapies in feline mammary carcinoma

Gameiro, Andreia; Urbano, Ana Catarina; Ferreira, Fernando

http://hdl.handle.net/10400.5/23404

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Autores

Gameiro, Andreia

Urbano, Ana Catarina

Ferreira, Fernando

Resumo(s)

ABSTRACT - : Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC development, using the knowledge gained from studies on human breast cancer to discover new diagnostic and prognostic biomarkers, thus reinforcing the utility of the cat as a cancer model. In this article, we review the current knowledge on FMC pathogenesis, biomarkers, and prognosis factors and offer new insights into novel therapeutic options for HER2-positive and triple-negative FMC subtypes.

Descrição

Research Areas: Veterinary Sciences

Palavras-chave

Feline mammary carcinoma Biomarkers Feline her2 mutations Targeted therapies Comparative oncology model

URI

http://hdl.handle.net/10400.5/23404

Citação

Gameiro A, Urbano AC, Ferreira F. 2021. Emerging biomarkers and targeted therapies in feline mammary carcinoma. Veterinary Sciences, 8(8):164. Doi: 10.3390/vetsci8080164