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Advisor(s)
Abstract(s)
ABSTRACT - : Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival
rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been
made to understand the molecular mechanisms underlying FMC development, using the knowledge
gained from studies on human breast cancer to discover new diagnostic and prognostic biomarkers,
thus reinforcing the utility of the cat as a cancer model. In this article, we review the current
knowledge on FMC pathogenesis, biomarkers, and prognosis factors and offer new insights into
novel therapeutic options for HER2-positive and triple-negative FMC subtypes.
Description
Research Areas: Veterinary Sciences
Keywords
Feline mammary carcinoma Biomarkers Feline her2 mutations Targeted therapies Comparative oncology model
Pedagogical Context
Citation
Gameiro A, Urbano AC, Ferreira F. 2021. Emerging biomarkers and targeted therapies in feline mammary carcinoma. Veterinary Sciences, 8(8):164. Doi: 10.3390/vetsci8080164
Publisher
MDPI