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Cinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugs

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dc.contributor.authorSilva, Ana Teresa
dc.contributor.authorBento, Clara M.
dc.contributor.authorPena, Ana C
dc.contributor.authorFigueiredo, Luisa M.
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorAguiar, Luísa
dc.contributor.authorSilva, Tânia
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorGomes, Maria Salomé
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Paula
dc.date.accessioned2021-12-10T14:31:14Z
dc.date.available2021-12-10T14:31:14Z
dc.date.issued2019
dc.description© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractCinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research.pt_PT
dc.description.sponsorshipThis research was funded by Fundação para a Ciência e Tecnologia (FCT), Portugal, grants UID/QUI/50006/2019, and PTDC/BTM-SAL/29786/2017.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMolecules. 2019 Dec 24;25(1):66pt_PT
dc.identifier.doi10.3390/molecules25010066pt_PT
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10451/50334
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationA small couple against the big three
dc.relation.publisherversionhttps://www.mdpi.com/journal/moleculespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAmidept_PT
dc.subjectAminoquinolinept_PT
dc.subjectAntimalarialpt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntiparasiticpt_PT
dc.subjectAntiproliferativept_PT
dc.subjectArtemisininpt_PT
dc.subjectChloroquinept_PT
dc.subjectCinnamicpt_PT
dc.subjectIonic liquidpt_PT
dc.subjectPrimaquinept_PT
dc.subjectRepurposingpt_PT
dc.subjectRescuingpt_PT
dc.titleCinnamic acid conjugates in the rescuing and repurposing of classical antimalarial drugspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleA small couple against the big three
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-SAL%2F29786%2F2017/PT
oaire.citation.issue1pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume25pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNamePena
person.familyNameFigueiredo
person.familyNameTeixeira
person.givenNameAna
person.givenNameLuisa M
person.givenNameCátia
person.identifier.ciencia-id421C-420D-E7BD
person.identifier.ciencia-id8F18-9278-8A02
person.identifier.orcid0000-0002-0973-599X
person.identifier.orcid0000-0002-5752-6586
person.identifier.orcid0000-0001-9506-3781
person.identifier.ridP-5505-2017
person.identifier.scopus-author-id36342641900
person.identifier.scopus-author-id23981482200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication94e12e6d-b9ae-4d78-89b8-4cad0fc8885e
relation.isAuthorOfPublication996632d8-b4b7-45ab-903f-aec092718a0d
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