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Comparação da cinética de libertação de flúor em pastas fluoretadas
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Objetivo: Comparar a cinética de libertação de flúor para a saliva de três dentífricos com concentrações distintas, avaliar o seu impacto no fluxo salivar e determinar possíveis efeitos toxicológicos. Desenho de estudo: Ensaio clínico aleatório duplamente cego – Estudo piloto Materiais e métodos: Amostra constituída por 10 voluntários, da Faculdade de Medicina Dentária da Universidade de Lisboa, distribuída em triplo cross-over. Todos os participantes experimentaram os três dentífricos. Determinou-se o fluxo salivar basal por métodos pré-estabelecidos nos tempos definidos. Após escovagem determinou-se o fluxo salivar, a quantidade de flúor no bochecho, retida na escova e libertada na saliva durante duas horas após a escovagem, recorrendo a métodos potenciómetros e a um microeléctrodo de flúor. Resultados: A escovagem dentária não induz alterações estatisticamente significativas no fluxo salivar (P>0,05). Embora o padrão de cinética de libertação seja semelhante nos três dentífricos, existe um pico nos 5 minutos iniciais, estatisticamente superior para a Colgate Duraphat® (P<0,05). Esta é colocada em menor quantidade (P<0,05) contudo apresenta maior quantidade de flúor aplicado (P<0,05) e libertado na saliva (P<0,05) comparativamente aos outros dentífricos estudados. Conclusão: O fluxo salivar não depende dos produtos utilizados neste estudo. Associado a estes resultados, a cinética e a quantidade de flúor libertada por estes produtos apresenta-se como potencialmente protetora de efeitos desmineralizantes. Com base nos resultados deste estudo, não existe risco de toxicidade aguda ou crónica para um adulto que escove os dentes com qualquer uma das pastas dentífricas, segundo as recomendações do médico dentista.
Objectives: This study compares the fluoride kinetics between three dentifrices with different concentrations and also evaluates their impact on salivary flow rate and possible toxic effects. Design: Double blind randomized controlled trial. Materials and methods: 20 students’ sample from Dental Medicine University of Lisbon were randomly recruited and distributed between three cross-over groups. All volunteers experienced the three toothpastes. The baseline salivary flow was determined through pre-established methods during the defined times. After brushing for two hours, the salivary flow was determined, as well as the amount of fluoride in rinse, retained on toothbrush and released to saliva, through microelectrode, and meter technics. Results: Brushing the teeth with these products does not induce significant alterations in salivary flow (P> 0.05). Although the fluoride kinetics is similar in the three toothpastes, there is a peak at the initial 5 minutes, statistically superior in Colgate Duraphat ® (P <0.05). Despite being put to a lesser extent in the toothbrush (P <0.05) it has higher amount of fluoride applied (P <0.05) and released in saliva (P <0.05) compared to other toothpastes in this study. Conclusion: The salivary flow rate does not depend on the toothpastes concentrations’. Associated to these results, are the kinetics and the amount of fluoride released by these products, which may a have protective effect on demineralization. Based on the results of this study, there is no risk of acute or chronic toxicity for an adult who brush the teeth with any of the toothpaste, following the guidelines of the dentist.
Objectives: This study compares the fluoride kinetics between three dentifrices with different concentrations and also evaluates their impact on salivary flow rate and possible toxic effects. Design: Double blind randomized controlled trial. Materials and methods: 20 students’ sample from Dental Medicine University of Lisbon were randomly recruited and distributed between three cross-over groups. All volunteers experienced the three toothpastes. The baseline salivary flow was determined through pre-established methods during the defined times. After brushing for two hours, the salivary flow was determined, as well as the amount of fluoride in rinse, retained on toothbrush and released to saliva, through microelectrode, and meter technics. Results: Brushing the teeth with these products does not induce significant alterations in salivary flow (P> 0.05). Although the fluoride kinetics is similar in the three toothpastes, there is a peak at the initial 5 minutes, statistically superior in Colgate Duraphat ® (P <0.05). Despite being put to a lesser extent in the toothbrush (P <0.05) it has higher amount of fluoride applied (P <0.05) and released in saliva (P <0.05) compared to other toothpastes in this study. Conclusion: The salivary flow rate does not depend on the toothpastes concentrations’. Associated to these results, are the kinetics and the amount of fluoride released by these products, which may a have protective effect on demineralization. Based on the results of this study, there is no risk of acute or chronic toxicity for an adult who brush the teeth with any of the toothpaste, following the guidelines of the dentist.
Descrição
Tese de mestrado, Medicina Dentária, Universidade de Lisboa, Faculdade de Medicina Dentária, 2012
Palavras-chave
Cariologia Teses de mestrado - 2012