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Incidência de lesão renal aguda nos doentes internados por SARS-COV-2, no Hospital Beatriz Ângelo
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Introdução: A Lesão Renal Aguda (LRA) está descrita como fator de gravidade em diversas doenças, incluindo em doentes com doença de coronavírus 2019 (COVID- 19). O objetivo deste estudo é avaliar a incidência, a letalidade e fatores preditores de LRA em doentes internados por COVID-19 numa unidade hospitalar. Métodos: Foram selecionados doentes adultos, COVID-19 positivos, identificados por teste Polymerase Chain Reaction ou por pesquisa de antigénio através de uma amostra de exsudado nasofaríngeo. O diagnóstico de LRA foi feito através da variação dos valores de Creatinina Sérica (CrS), de acordo com os critérios KDIGO. Resultados: Foram incluídos no estudo 239 doentes, internados no Hospital Beatriz Ângelo, no mês de janeiro de 2021, dos quais 62 (25,94%) com LRA. Foram encontradas correlações entre LRA e a idade, o índice de Barthel, o pH, e o número de leucócitos/mm3 no hemograma da admissão. Observou-se que a LRA tem um elevado valor prognóstico nos doentes, uma vez que a letalidade da doença é maior nos doentes com LRA. Conclusão: A possibilidade de LRA num doente com COVID-19 deverá ser tida sempre em conta, uma vez que uma abordagem precoce, com a identificação de doentes de risco para desenvolver esta patologia, quer pelos fatores demográficos, quer por fatores laboratoriais, são essenciais para diminuir a letalidade associada à COVID-19. Este estudo permite uma melhor abordagem e compreensão dirigida à população Portuguesa para o futuro.
Introduction: Acute Kidney Injury (AKI) is described as a severity factor in several diseases, including in patients with coronavirus disease 2019 (COVID-19). The aim of this study is to evaluate the incidence, lethality, and predictive factors of AKI in COVID-19 patients. Methods: Adult COVID-19 positive patients were identified by Polymerase Chain Reaction test or antigen test through a nasopharyngeal swab sample. The identification of AKI was made through the variation of values of serum creatinine, according to the KDIGO criteria. Results: A total of 239 patients were included in the study, of whom 62 (25.94%) with AKI. Correlations were found between AKI and age, Barthel's index, pH, and leukocyte count/mm3 on hemogram at admission. It was observed that AKI has a high prognostic value in patients, since the lethality of the disease is higher in patients with AKI. Conclusion: The possibility of AKI in a patient with COVID-19 should always be considered, since an early approach, with the identification of patients at risk of developing this pathology, either due to demographic factors or laboratory factors, are essential to decrease lethality associated with COVID-19. This study allows a better approach and understanding of the disease in the Portuguese population for the future.
Introduction: Acute Kidney Injury (AKI) is described as a severity factor in several diseases, including in patients with coronavirus disease 2019 (COVID-19). The aim of this study is to evaluate the incidence, lethality, and predictive factors of AKI in COVID-19 patients. Methods: Adult COVID-19 positive patients were identified by Polymerase Chain Reaction test or antigen test through a nasopharyngeal swab sample. The identification of AKI was made through the variation of values of serum creatinine, according to the KDIGO criteria. Results: A total of 239 patients were included in the study, of whom 62 (25.94%) with AKI. Correlations were found between AKI and age, Barthel's index, pH, and leukocyte count/mm3 on hemogram at admission. It was observed that AKI has a high prognostic value in patients, since the lethality of the disease is higher in patients with AKI. Conclusion: The possibility of AKI in a patient with COVID-19 should always be considered, since an early approach, with the identification of patients at risk of developing this pathology, either due to demographic factors or laboratory factors, are essential to decrease lethality associated with COVID-19. This study allows a better approach and understanding of the disease in the Portuguese population for the future.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2023
Palavras-chave
Lesão renal aguda SARS-CoV-2 COVID-19 Epidemiologia Nefrologia