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Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regeneration: An Experimental Approach from Fundamental to Translational Research

2023-03-06Journal article Open access
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dc.contributor.authorFrancisco, Pedro
dc.contributor.authorNeves Amaral, Mariana
dc.contributor.authorNeves, Afonso
dc.contributor.authorFerreira-Gonçalves, Tânia
dc.contributor.authorViana, Ana S.
dc.contributor.authorCatarino, José
dc.contributor.authorFaísca, Pedro
dc.contributor.authorSimões, Sandra
dc.contributor.authorPerdigão, João
dc.contributor.authorCharmier, Adília J.
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorReis, Catarina Pinto
dc.date.accessioned2023-09-14T07:37:07Z
dc.date.available2023-09-14T07:37:07Z
dc.date.issued2023-03-06
dc.date.updated2023-03-13T20:07:45Z
dc.description.abstractPresently, skin burns are considered one of the main public health problems and lack therapeutic options. In recent years, silver nanoparticles (AgNPs) have been widely studied, playing an increasingly important role in wound healing due to their antibacterial activity. This work is focused on the production and characterization of AgNPs loaded in a Pluronic® F127 hydrogel, as well as assessing its antimicrobial and wound-healing potential. Pluronic® F127 has been extensively explored for therapeutic applications mainly due to its appealing properties. The developed AgNPs had an average size of 48.04 ± 14.87 nm (when prepared by method C) and a negative surface charge. Macroscopically, the AgNPs solution presented a translucent yellow coloration with a characteristic absorption peak at 407 nm. Microscopically, the AgNPs presented a multiform morphology with small sizes (~50 nm). Skin permeation studies revealed that no AgNPs permeated the skin after 24 h. AgNPs further demonstrated antimicrobial activity against different bacterial species predominant in burns. A chemical burn model was developed to perform preliminary in vivo assays and the results showed that the performance of the developed AgNPs loaded in hydrogel, with smaller silver dose, was comparable with a commercial silver cream using higher doses. In conclusion, hydrogel-loaded AgNPs is potentially an important resource in the treatment of skin burns due to their proven efficacy by topical administration.pt_PT
dc.description.sponsorshipThe authors gratefully acknowledge Fundação para a Ciência e a Tecnologia (FCT) through projects UIDB/04138/2020, UIDP/04138/2020, UIDB/00645/2020, UIDB/00100/2020 and UIDP/00100/2020. M.N.A. would like to thank FCT for the PhD Fellowship SFRH/BD/05377/2021, and T.F.-G. for the PhD Fellowship SFRH/BD/147306/2019. J.P. is supported by FCT through Estímulo Individual ao Emprego Científico [CEECIND/00394/2017].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFrancisco P, Neves Amaral M, Neves A, Ferreira-Gonçalves T, Viana AS, Catarino J, et al. Pluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regeneration: An Experimental Approach from Fundamental to Translational Research. Gels [Internet]. 2023 Mar 6;9(3):200. Available from: http://dx.doi.org/10.3390/gels9030200pt_PT
dc.identifier.doi10.3390/gels9030200pt_PT
dc.identifier.issn2310-2861
dc.identifier.slugcv-prod-3167239
dc.identifier.urihttp://hdl.handle.net/10451/59279
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUIDB/04138/2020pt_PT
dc.relationUIDP/04138/2020pt_PT
dc.relationUIDB/00645/2020pt_PT
dc.relationUIDB/00100/2020pt_PT
dc.relationUIDP/00100/2020pt_PT
dc.relationSFRH/BD/05377/2021pt_PT
dc.relationSFRH/BD/147306/2019pt_PT
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/2310-2861/9/3/200pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectsilver nanoparticlespt_PT
dc.subjectburnspt_PT
dc.subjectwound healingpt_PT
dc.subjectnanotechnologypt_PT
dc.subjecttopical administrationpt_PT
dc.titlePluronic® F127 Hydrogel Containing Silver Nanoparticles in Skin Burn Regeneration: An Experimental Approach from Fundamental to Translational Researchpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00394%2F2017%2FCP1476%2FCT0001/PT
oaire.citation.issue3pt_PT
oaire.citation.startPage200pt_PT
oaire.citation.titleGelspt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamCEEC IND 2017
person.familyNameGonçalves
person.familyNameSimões
person.familyNameLucas Mota Perdigão
person.familyNamede Jesus Guilherme Gaspar
person.familyNameBeco Pinto Reis
person.givenNameTânia
person.givenNameSandra
person.givenNameJoão Ruben
person.givenNameMaria Manuela
person.givenNameAna Catarina
person.identifierC-2614-2014
person.identifierC-2024-2014
person.identifierM-8132-2013
person.identifier.ciencia-id2914-A05C-F762
person.identifier.ciencia-id4011-196E-E4EA
person.identifier.ciencia-id991C-F26A-9843
person.identifier.ciencia-id3A10-0732-13F5
person.identifier.ciencia-id1317-A7D6-3B1C
person.identifier.orcid0000-0001-9916-3907
person.identifier.orcid0000-0002-5685-1790
person.identifier.orcid0000-0002-0339-1305
person.identifier.orcid0000-0001-6814-7226
person.identifier.orcid0000-0002-1046-4031
person.identifier.scopus-author-id57218871355
person.identifier.scopus-author-id8724939200
person.identifier.scopus-author-id24723211800
person.identifier.scopus-author-id15834627800
person.identifier.scopus-author-id14027161300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid991C-F26A-9843 | João Ruben Lucas Mota Perdigão
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication17957fc5-a727-4574-903e-c47af915975d
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