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Synthetically defined glycoprotein vaccines: current status and future directions

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dc.contributor.authorAdamo, Roberto
dc.contributor.authorNilo, Alberto
dc.contributor.authorCastagner, Bastien
dc.contributor.authorBoutureira, Omar
dc.contributor.authorBerti, Francesco
dc.contributor.authorBernardes, Gonçalo J. L.
dc.date.accessioned2022-01-19T11:24:00Z
dc.date.available2022-01-19T11:24:00Z
dc.date.issued2013
dc.descriptionThis journal is © The Royal Society of Chemistry 2013. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.pt_PT
dc.description.abstractPrimary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationChem Sci. 2013 Aug 1;4(8):2995-3008pt_PT
dc.identifier.doi10.1039/c3sc50862ept_PT
dc.identifier.eissn2041-6539
dc.identifier.issn2041-6520
dc.identifier.urihttp://hdl.handle.net/10451/50883
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relation.publisherversionhttps://pubs.rsc.org/en/journals/journalissues/sc#!recentarticles&advpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleSynthetically defined glycoprotein vaccines: current status and future directionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3008pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage2995pt_PT
oaire.citation.titleChemical Sciencept_PT
oaire.citation.volume4pt_PT
person.familyNameBernardes
person.givenNameGonçalo
person.identifier.orcid0000-0001-6594-8917
person.identifier.scopus-author-id14046757500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd1a48067-77b1-4413-b1c7-602fb18c62c0
relation.isAuthorOfPublication.latestForDiscoveryd1a48067-77b1-4413-b1c7-602fb18c62c0

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