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Impaired fasting glucose and chronic kidney disease, albuminuria, or worsening kidney function: a secondary analysis of SPRINT

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dc.contributor.authorVieira, Miguel Bigotte
dc.contributor.authorNeves, João Sérgio
dc.contributor.authorLeitão, Lia
dc.contributor.authorBaeta Baptista, Rute
dc.contributor.authorMagriço, Rita
dc.contributor.authorViegas Dias, Catarina
dc.contributor.authorOliveira, Ana
dc.contributor.authorCarvalho, Davide
dc.contributor.authorMc Causland, Finnian R
dc.date.accessioned2022-05-09T15:40:03Z
dc.date.available2022-05-09T15:40:03Z
dc.date.issued2019
dc.descriptionCopyright © 2019 Endocrine Societypt_PT
dc.description.abstractPurpose: Diabetes mellitus is a risk factor for the development and progression of chronic kidney disease (CKD). However, the association of prediabetes with adverse kidney outcomes is uncertain. Methods: We performed a secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT), including 9,361 participants without diabetes at baseline. We categorized participants according to fasting glucose as having impaired fasting glucose (≥100 mg/dL [(≥5.6 mmol/L]) or normoglycemia (<100 mg/dL [(<5.6 mmol/L]). Unadjusted and adjusted proportional hazards models were fit to estimate the association of impaired fasting glucose (versus normoglycemia) with a composite outcome of worsening kidney function (≥30% decrease in eGFR to <60 ml/min/1.73 m2 in participants without baseline CKD; ≥50% decrease in eGFR or need of long-term dialysis/kidney transplantation in participants with CKD) or incident albuminuria (doubling of urinary albumin to creatinine ratio from <10 mg/g to >10 mg/g). These outcomes were also evaluated separately, and according to CKD status at baseline. Results: The mean age was 67.9 ± 9.4 years, 35.5% were female, and 31.4% were black. The median follow-up was 3.3 years and 41.8% had impaired fasting glucose. Impaired fasting glucose was not associated with higher rates of the composite outcome (HR 0.97; 95%CI 0.81-1.16), worsening kidney function (HR 1.02; 95%CI 0.75-1.37), or albuminuria (HR 0.98; 95%CI 0.78-1.23). Similarly, there was no association of impaired fasting glucose with outcomes according to baseline CKD status. Conclusions: Impaired fasting glucose at baseline was not associated with the development of worsening kidney function or albuminuria in participants of SPRINT.pt_PT
dc.description.sponsorshipThe SPRINT trial was sponsored by the National Heart, Lung, and Blood Institute (NHLBI), with cosponsorship by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the National Institute on Aging. F.R.M. is supported by the National Institute of Diabetes and Digestive and Kidney Diseases grant K23DK102511.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Clin Endocrinol Metab. 2019 May 7;104(9):4024-4032pt_PT
dc.identifier.doi10.1210/jc.2019-00073pt_PT
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.urihttp://hdl.handle.net/10451/52812
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttps://academic.oup.com/jcempt_PT
dc.titleImpaired fasting glucose and chronic kidney disease, albuminuria, or worsening kidney function: a secondary analysis of SPRINTpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4032pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage4024pt_PT
oaire.citation.titleThe Journal of Clinical Endocrinology & Metabolismpt_PT
oaire.citation.volume104pt_PT
person.familyNameBigotte Vieira
person.familyNameBaeta Baptista
person.givenNameMiguel
person.givenNameRute
person.identifier591378
person.identifier.ciencia-idFF17-2C76-E2CC
person.identifier.ciencia-id7614-FA6B-270F
person.identifier.orcid0000-0003-0528-2716
person.identifier.orcid0000-0002-7572-2812
person.identifier.ridV-4629-2018
person.identifier.scopus-author-id57192837006
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8d118e09-0abf-4347-8e5c-cc53c7cbd4bd
relation.isAuthorOfPublicationc13d7193-7985-4594-9954-4d138bd9317a
relation.isAuthorOfPublication.latestForDiscoveryc13d7193-7985-4594-9954-4d138bd9317a

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