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Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca

2022Artigo científico Acesso aberto
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dc.contributor.authorFeijão, Eduardo
dc.contributor.authorCruz de Carvalho, Ricardo
dc.contributor.authorDuarte, Irina A.
dc.contributor.authorMatos, Ana Rita
dc.contributor.authorCabrita, Maria Teresa
dc.contributor.authorUtkin, Andrei B.
dc.contributor.authorCaçador, Isabel
dc.contributor.authorMarques, João Carlos
dc.contributor.authorNovais, Sara C.
dc.contributor.authorLemos, Marco F. L.
dc.contributor.authorReis-Santos, Patrick
dc.contributor.authorFonseca, Vanessa F.
dc.contributor.authorDuarte, Bernardo
dc.date.accessioned2022-10-25T15:23:25Z
dc.date.available2022-10-25T15:23:25Z
dc.date.issued2022
dc.description.abstractEmerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reach marine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most prescribed selective serotonin reuptake inhibitors globally and has been detected in aquatic ecosystems in concentrations up to 40 μg L−1 . The present study aims to evaluate the impact of fluoxetine ecotoxicity on the photochemistry, energy metabolism and enzyme activity of Ulva lactuca exposed to environmentally relevant concentrations (0.3, 0.6, 20, 40, and 80 μg L−1 ). Exogenous fluoxetine exposure induced negative impacts on U. lactuca photochemistry, namely on photosystem II antennae grouping and energy fluxes. These impacts included increased oxidative stress and elevated enzymatic activity of ascorbate peroxidase and glutathione reductase. Lipid content increased and the altered levels of key fatty acids such as hexadecadienoic (C16:2) and linoleic (C18:2) acids revealed strong correlations with fluoxetine concentrations tested. Multivariate analyses reinforced the oxidative stress and chlorophyll a fluorescence-derived traits as efficient biomarkers for future toxicology studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFeijão, E., Cruz de Carvalho, R., Duarte, Irina A., Matos, A. R., Cabrita, M. T., Utkin, A. B., Caçador, I., Marques J. C., Novais, S. C., Lemos, M. F. L., Reis-Santos, P., Fonseca, V. F., & Duarte, B. (2022). Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca. Frontiers in Environmental Science, 10, 963537. https://doi.org/10.3389/fenvs.2022.963537pt_PT
dc.identifier.doi10.3389/fenvs.2022.963537pt_PT
dc.identifier.issn2296-665X
dc.identifier.urihttp://hdl.handle.net/10451/54879
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationMARE (UIDB/ 04292/2020 and UIDP/04292/2020)pt_PT
dc.relationARNET-Aquatic Research Infrastructure Network Associated Laboratory (LA/P/0069/2020)pt_PT
dc.relationBioISI (UID/MULTI/04046/2019)pt_PT
dc.relationPTDC/ CTA-AMB/30056/2017pt_PT
dc.relationProgramme of SR&TD SmartBioR (reference Centro-01-0145-FEDER-000018)pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fenvs.2022.963537/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntidepressantspt_PT
dc.subjectMacroalgaept_PT
dc.subjectOxidative stresspt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectPhotobiologypt_PT
dc.titleFluoxetine induces photochemistry-derived oxidative stress on Ulva lactucapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage963537pt_PT
oaire.citation.titleFrontiers in Environmental Sciencept_PT
oaire.citation.volume10pt_PT
person.familyNameCabrita
person.givenNameMaria Teresa
person.identifier349469
person.identifier.ciencia-id3E17-0125-F909
person.identifier.orcid0000-0002-4323-4945
person.identifier.ridB-5746-2014
person.identifier.scopus-author-id6602224932
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcac05d5d-1ba9-4d1a-a052-d8bde9ecfadc
relation.isAuthorOfPublication.latestForDiscoverycac05d5d-1ba9-4d1a-a052-d8bde9ecfadc

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