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Rho kinase inhibitors - a review on the physiology and clinical use in Ophthalmology

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dc.contributor.authorMoura Coelho, Nuno
dc.contributor.authorTavares Ferreira, Joana
dc.contributor.authorBruxelas, Carolina Pereira
dc.contributor.authorDutra Medeiros, Marco
dc.contributor.authorCunha, João Paulo
dc.contributor.authorPinto Proença, Rita
dc.date.accessioned2020-10-28T11:49:14Z
dc.date.available2020-10-28T11:49:14Z
dc.date.issued2019
dc.description© 2020 Springer Nature Switzerland AG. Part of Springer Nature.pt_PT
dc.description.abstractThe Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. These roles in corneal and glaucomatous disease states have led to the growing interest in the development of drugs selectively targeting this pathway (ROCK inhibitors). The authors provide a review of the literature on the pathobiology of the ROCK signaling in corneal endothelial disease, glaucoma, and vitreoretinal disease, as well as the clinical usefulness of ROCK inhibitors in Ophthalmology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoura-Coelho, N., Tavares Ferreira, J., Bruxelas, C. et al. (2019) Rho kinase inhibitors—a review on the physiology and clinical use in Ophthalmology. Graefes Arch Clin Exp Ophthalmol 257, 1101–1117pt_PT
dc.identifier.doi10.1007/s00417-019-04283-5pt_PT
dc.identifier.issn1435-702X
dc.identifier.urihttp://hdl.handle.net/10451/44689
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs00417-019-04283-5pt_PT
dc.subjectCorneal endothelial diseasept_PT
dc.subjectGlaucomapt_PT
dc.subjectRho kinasept_PT
dc.subjectRho kinase inhibitorspt_PT
dc.subjectVitreoretinal diseasept_PT
dc.titleRho kinase inhibitors - a review on the physiology and clinical use in Ophthalmologypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1117pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1101pt_PT
oaire.citation.titleGraefe's Archive for Clinical and Experimental Ophthalmologypt_PT
oaire.citation.volume257pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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