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Harmless or Threatening? Interpreting the Results of Molecular Diagnosis in the Context of Virus-Host Relationships

2021-05-21Journal article Open access
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dc.contributor.authorAbade dos Santos, Fábio A.
dc.contributor.authorPortela, Sara J.
dc.contributor.authorNogueira, Teresa
dc.contributor.authorCarvalho, Carina L.
dc.contributor.authorde Sousa, Rita
dc.contributor.authorDuarte, Margarida D.
dc.date.accessioned2021-05-31T12:48:31Z
dc.date.available2021-05-31T12:48:31Z
dc.date.issued2021-05-21
dc.description.abstractMolecular methods, established in the 1980s, expanded and delivered tools for the detection of vestigial quantities of nucleic acids in biological samples. Nucleotide sequencing of these molecules reveals the identity of the organism it belongs to. However, the implications of such detection are often misinterpreted as pathogenic, even in the absence of corroborating clinical evidence. This is particularly significant in the field of virology where the concepts of commensalism, and other benign or neutral relationships, are still very new. In this manuscript, we review some fundamental microbiological concepts including commensalism, mutualism, pathogenicity, and infection, giving special emphasis to their application in virology, in order to clarify the difference between detection and infection. We also propose a system for the correct attribution of terminology in this context.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAbade dos Santos FA, Portela SJ, Nogueira T, Carvalho CL, de Sousa R and Duarte MD (2021) Harmless or Threatening? Interpreting the Results of Molecular Diagnosis in the Context of Virus-Host Relationships. Front. Microbiol. 12:647730. doi: 10.3389/fmicb.2021.647730pt_PT
dc.identifier.doi10.3389/fmicb.2021.647730pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/48257
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationFCT SFRH/BD/137067/2018pt_PT
dc.relationFCT UIDB/00276/2020pt_PT
dc.relationFCT UIDP/00329/2020pt_PT
dc.relationFundo Florestal Permanente Project + Coelho, ref no. 2017014300001pt_PT
dc.relationALG-01-0145-FEDER-028824pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjecthost-pathogen, detection, infection, commensalism, mutualism, molecular biology interpretationpt_PT
dc.titleHarmless or Threatening? Interpreting the Results of Molecular Diagnosis in the Context of Virus-Host Relationshipspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volume12pt_PT
person.familyNameVitorino Nogueira
person.givenNameTeresa Isabel
person.identifierG-2273-2010
person.identifier.ciencia-idF211-4E18-2C69
person.identifier.orcid0000-0002-0059-5177
person.identifier.scopus-author-id7004351448
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfd1c0a47-fb41-49e1-a4c9-2575917bc120
relation.isAuthorOfPublication.latestForDiscoveryfd1c0a47-fb41-49e1-a4c9-2575917bc120

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