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Complete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter study

2023Journal article Open access
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dc.contributor.authorFevereiro-Martins, Mariza
dc.contributor.authorSantos, Ana Carolina
dc.contributor.authorMarques-Neves, Carlos
dc.contributor.authorGuimarães, Hercília
dc.contributor.authorBicho, Manuel
dc.contributor.authorAfonso, Conceição
dc.contributor.authorFerreira, Joana
dc.contributor.authorSanto, Rita Espírito
dc.contributor.authorJorge Teixeira, Filipa
dc.contributor.authorRosa, Rita
dc.contributor.authorCarneiro, Cristina Vaz
dc.contributor.authorFerreira, Marta
dc.contributor.authorMatos, Teresa
dc.contributor.authorNeiva, Luísa
dc.contributor.authorPereira, Sandra
dc.contributor.authorAires, Sofia
dc.contributor.authorParreira, Ricardo
dc.contributor.authorMelnik, Zuzana
dc.contributor.authorFaria, João
dc.contributor.authorTeixeira, Joana
dc.contributor.authorBarros, Pedro
dc.contributor.authorAlmeida, Juliana
dc.contributor.authorMalheiro, Bruna
dc.contributor.authorRodrigues, Patrícia Cunha
dc.contributor.authorAlbuquerque, Luís
dc.contributor.authorFreitas, Alice
dc.contributor.authorKotchekova, Nadezda
dc.contributor.authorFreitas, Rui
dc.contributor.authorSilveira, Ana Cristina
dc.contributor.authorFerreira, Ana
dc.contributor.authorMorais, Benvinda
dc.contributor.authorTeixeira, Susana
dc.contributor.authorMota, Mafalda
dc.contributor.authorGuerra, Maria
dc.contributor.authorCoimbra, Lúcia
dc.contributor.authorGigante, João
dc.contributor.authorFerreira, Muriel
dc.contributor.authorLapa, Patrícia
dc.contributor.authorMonteiro, Madalena
dc.contributor.authorAlfaiate, Mário
dc.contributor.authorRodrigues, Teresa
dc.contributor.authorPina, Teresa
dc.contributor.authorRosário, Marta
dc.contributor.authorSilva, Renato
dc.contributor.authorBreda, Jorge
dc.contributor.authorBazenga, Filipa
dc.contributor.authorPinto, João António
dc.date.accessioned2023-05-03T13:22:34Z
dc.date.available2023-05-03T13:22:34Z
dc.date.issued2023
dc.description© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.pt_PT
dc.description.abstractPurpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory data from the first week of life were collected. Univariate logistic regression was used to assess risk factors for ROP and then multivariate regression was performed. Results: A total of 455 infants were included in the study. The median GA was 29.6 weeks, and the median birth weight was 1295 g. One hundred and seventy-two infants (37.8%) developed ROP. Median values of erythrocytes (p < 0.001), hemoglobin (p < 0.001), hematocrit (p < 0.001), mean corpuscular hemoglobin concentration (p < 0.001), lymphocytes (p = 0.035), and platelets (p = 0.003) of the group of infants diagnosed with ROP any stage were lower than those without ROP. Mean corpuscular volume (MCV) (p = 0.044), red blood cell distribution width (RDW) (p < 0.001), erythroblasts (p < 0.001), neutrophils (p = 0.030), neutrophils-lymphocytes ratio (p = 0.028), and basophils (p = 0.003) were higher in the ROP group. Higher values of MCV, erythroblasts, and basophils remained significantly associated with ROP after multivariate regression. Conclusion: In our cohort, the increase in erythroblasts, MCV, and basophils in the first week of life was significantly and independently associated with the development of ROP. These CBC parameters may be early predictive biomarkers for ROP.pt_PT
dc.description.sponsorshipOpen access funding provided by FCT|FCCN (b-on). This work was supported by the Laboratório de Genética and the Instituto de Saúde Ambiental (ISAMB) of the Faculdade de Medicina of Universidade de Lisboa and the Instituto de Investigação Científica Bento da Rocha Cabral. The writing of the manuscript was also supported by funds from Fundação para a Ciência e a Tecnologia to ISAMB (ref. UIDB/04295/2020 and UIDP/04295/2020). This work was also part of a doctoral project funding by the company CUF with a PhD grant in Medicine awarded in 2021 and by the Portuguese Society of Ophthalmology with a PhD grant awarded in 2019.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGraefes Arch Clin Exp Ophthalmol. 2023;10.1007/s00417-023-06072-7pt_PT
dc.identifier.doi10.1007/s00417-023-06072-7pt_PT
dc.identifier.eissn1435-702X
dc.identifier.issn0721-832X
dc.identifier.urihttp://hdl.handle.net/10451/57328
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relationEnvironmental Health Institute
dc.relationEnvironmental Health Institute
dc.relation.publisherversionhttps://www.springer.com/journal/417pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiomarkerpt_PT
dc.subjectComplete blood countpt_PT
dc.subjectPreterm infantpt_PT
dc.subjectRetinopathy of prematuritypt_PT
dc.titleComplete blood count parameters as biomarkers of retinopathy of prematurity: a Portuguese multicenter studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEnvironmental Health Institute
oaire.awardTitleEnvironmental Health Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04295%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04295%2F2020/PT
oaire.citation.titleGraefe's Archive for Clinical and Experimental Ophthalmologypt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFevereiro-Martins
person.familyNameCasinhas dos Santos
person.familyNameMarques Neves
person.familyNameGuimarães
person.familyNameBicho
person.familyNameFerreira
person.familyNameJorge Teixeira
person.givenNameMariza
person.givenNameAna Carolina
person.givenNameCarlos
person.givenNameHercília
person.givenNameManuel
person.givenNameJoana
person.givenNameFilipa
person.identifier3012902
person.identifierR-000-K5H
person.identifier1234753
person.identifier.ciencia-idC319-D454-CA47
person.identifier.ciencia-id6116-BD41-531E
person.identifier.ciencia-idC119-D580-13D6
person.identifier.ciencia-id9F19-BE8C-B1DF
person.identifier.ciencia-id9512-8D22-1B28
person.identifier.orcid0000-0002-1875-6581
person.identifier.orcid0000-0003-3688-4648
person.identifier.orcid0000-0002-3842-2466
person.identifier.orcid0000-0001-6402-3285
person.identifier.orcid0000-0002-5773-5687
person.identifier.orcid0000-0002-3527-3274
person.identifier.orcid0000-0003-2884-8436
person.identifier.scopus-author-id6504812918
person.identifier.scopus-author-id7004057361
person.identifier.scopus-author-id7004153755
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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