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Authors
Abstract(s)
O presente trabalho integra o plano de estudos do Mestrado em Análises Clínicas da Faculdade de Farmácia da Universidade de Lisboa e constitui um dos seus principais objetos de avaliação. Este divide-se em duas partes: a primeira consiste num relatório de estágio de natureza profissional e a segunda é constituída pela monografia.
No relatório é apresentado o local onde decorreram as diferentes valências do estágio e pretende ser um resumo da experiência adquirida durante esse período, descrevendo os produtos biológicos, ensaios, metodologias e equipamentos utilizados em cada valência e a importância de cada uma em ambiente de laboratório hospitalar. Refere também os procedimentos adotados pelo laboratório ao nível do controlo de qualidade interno e avaliação externa da qualidade.
O estágio decorreu entre 1 de junho e 12 de outubro de 2021 e foi realizado no Laboratório de Patologia Clínica do Hospital CUF Tejo em Lisboa que é gerido pelo Centro de Medicina Laboratorial Germano de Sousa. As valências de Bioquímica, Hematologia e Microbiologia serão apresentadas neste relatório sendo que a valência de Microbiologia também teve uma componente realizada no Laboratório Central do Grupo Germano de Sousa.
Na segunda parte deste trabalho – que corresponde à monografia – é apresentada uma revisão da literatura com o tema: “Patogénese e diagnóstico da infeção pelo vírus de Epstein-Barr: importância da latência viral”. O vírus de Epstein-Barr encontra-se difundido por todo o globo e desde a sua descoberta nos anos 60 continua a intrigar investigadores e clínicos que estudam o seu efeito na população humana. A monografia aborda as características deste vírus e a forma como este desenvolve doença nas mais variadas formas e a razão pelo qual nem todos os que estão infetados irão desenvolver doença. Irá ser também abordado como as propriedades de latência viral contribuem para a propagação deste vírus bem como o diagnóstico da infeção e perspetivas futuras no combate ao Epstein-Barr.
The present work is an integral part of the study plan of the Master in Laboratory Medicine by the Faculty of Pharmacy of University of Lisbon and it is one of their main evaluation tools. It is divided in two parts: the first one is a professional internship report and the second a literature review – a monograph. In the internship report there is an inicial presentation of the laboratory where the internship was carried out and the different sections. The report intends to be a summary of the acquired experience throughout the internship period, describing biological products, assays, methodologies and laboratory equipment from the diferent sections and their importance in a hospital laboratory. It also refers to the adopted procedures in the laboratory concerning the internal and external quality control. The internship occurred from June 1st to October 12th 2021 in the Clinical Pathology Laboratory of Cuf Tejo Hospital in Lisbon. This laboratory is managed by Centro de Medicina Laboratorial Germano de Sousa. The sections of Biochemistry, Hematology and Microbiology will be presented in this report enlightening that Microbiology also had a component performed at the central laboratory from the Germano de Sousa group. On the second part of this work – the monograph – a literature review is presented regarding the following topic: Pathogenesis and diagnosis of the Epstein-Barr virus infection: the importance of viral latency. The Epstein-Barr virus is spread across the entire globe and since its discovery in the 60’s it still intrigues investigators and clinicians who study its effect in the human host. This work delves into the virus characteristics, the way it induces different disease outcomes, and the reason why not all infected individuals will become ill. It also addresses how the viral latency properties of this virus contribute for its propagation as well as how the infection is diagnosed. Finally, a conclusion and future perspectives section is presented, pointing to how we can control and treat Epstein-Barr virus infection.
The present work is an integral part of the study plan of the Master in Laboratory Medicine by the Faculty of Pharmacy of University of Lisbon and it is one of their main evaluation tools. It is divided in two parts: the first one is a professional internship report and the second a literature review – a monograph. In the internship report there is an inicial presentation of the laboratory where the internship was carried out and the different sections. The report intends to be a summary of the acquired experience throughout the internship period, describing biological products, assays, methodologies and laboratory equipment from the diferent sections and their importance in a hospital laboratory. It also refers to the adopted procedures in the laboratory concerning the internal and external quality control. The internship occurred from June 1st to October 12th 2021 in the Clinical Pathology Laboratory of Cuf Tejo Hospital in Lisbon. This laboratory is managed by Centro de Medicina Laboratorial Germano de Sousa. The sections of Biochemistry, Hematology and Microbiology will be presented in this report enlightening that Microbiology also had a component performed at the central laboratory from the Germano de Sousa group. On the second part of this work – the monograph – a literature review is presented regarding the following topic: Pathogenesis and diagnosis of the Epstein-Barr virus infection: the importance of viral latency. The Epstein-Barr virus is spread across the entire globe and since its discovery in the 60’s it still intrigues investigators and clinicians who study its effect in the human host. This work delves into the virus characteristics, the way it induces different disease outcomes, and the reason why not all infected individuals will become ill. It also addresses how the viral latency properties of this virus contribute for its propagation as well as how the infection is diagnosed. Finally, a conclusion and future perspectives section is presented, pointing to how we can control and treat Epstein-Barr virus infection.
Description
Tese de mestrado, Análises Clínicas, 2023, Universidade de Lisboa, Faculdade de Farmácia.
Keywords
Bioquímica Hematologia Microbiologia Epstein-Barr Latência viral Teses de mestrado - 2023