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Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish

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dc.contributor.authorRibeiro, Ana
dc.contributor.authorMonteiro, Joana F.
dc.contributor.authorCertal, Ana C.
dc.contributor.authorCristovão, Ana
dc.contributor.authorSaúde, Leonor
dc.date.accessioned2022-02-23T16:43:52Z
dc.date.available2022-02-23T16:43:52Z
dc.date.issued2017
dc.description© 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are creditedpt_PT
dc.description.abstractZebrafish are able to regenerate the spinal cord and recover motor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal. Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that ependymal cells express Foxj1a from their birth in the embryonic neural tube and that Foxj1a activity is required for the final positioning of the ependymal canal. We also show that in response to spinal cord injury, Foxj1a ependymal cells actively proliferate and contribute to the restoration of the spinal cord structure. Finally, this study reveals that Foxj1a expression in the injured spinal cord is regulated by regulatory elements activated during regeneration. These data establish Foxj1a as a pan-ependymal marker in development, homeostasis and regeneration and may help identify the signals that enable this progenitor population to replace lost cells after spinal cord injury.pt_PT
dc.description.sponsorshipThis research was supported by FCT (Portugal) grants (PTDC/BIM-MED/1375/2012 and PTDC/BIM-MED/3295/2014) given to L.S. L.S. was supported by an IF contract from FCT (Portugal). A.R. was supported by a postdoctoral fellowship of the FCT (Portugal) (SFRH/BPD/100162/2014) and EMBO (605-2012)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOpen Biol. 2017 Nov;7(11):170139pt_PT
dc.identifier.doi10.1098/rsob.170139pt_PT
dc.identifier.eissn2046-2441
dc.identifier.urihttp://hdl.handle.net/10451/51484
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Societypt_PT
dc.relationVascular remodelling during spinal cord regeneration in zebrafish
dc.relation.publisherversionhttps://royalsocietypublishing.org/journal/rsobpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCSF-contacting neuronspt_PT
dc.subjectFoxj1apt_PT
dc.subjectShhpt_PT
dc.subjectEpendymal radial gliapt_PT
dc.subjectSpinal cord injurypt_PT
dc.subjectZebrafishpt_PT
dc.titleFoxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleVascular remodelling during spinal cord regeneration in zebrafish
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MED%2F1375%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIM-MED%2F3295%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBPD%2F100162%2F2014/PT
oaire.citation.issue11pt_PT
oaire.citation.titleOpen Biologypt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamOE
person.familyNameEsteves Ribeiro
person.familyNameTavares Saúde
person.givenNameAna Catarina
person.givenNameMaria Leonor
person.identifier.ciencia-idE114-BCC1-CA08
person.identifier.ciencia-id9A1D-82B1-3133
person.identifier.orcid0000-0003-0132-9740
person.identifier.orcid0000-0001-5933-8872
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication9e52f900-172b-473e-9635-38f0042c96b3
relation.isAuthorOfPublication.latestForDiscovery814dce26-6f5a-4f80-9ce5-c00d10300ba7
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