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Searching for “signal 2”: costimulation requirements of γδ T cells

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dc.contributor.authorRibot, Julie
dc.contributor.authorde Barros, Ana
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2021-09-29T11:20:55Z
dc.date.available2021-09-29T11:20:55Z
dc.date.issued2011
dc.description© Springer Basel AG 2011pt_PT
dc.description.abstractT cell activation requires the integration of signals that arise from various types of receptors. Although TCR triggering is a necessary condition, it is often not sufficient to induce full T-cell activation, as reflected in cell proliferation and cytokine secretion. This has been firmly demonstrated for conventional αβ T cells, for which a large panel of costimulatory receptors has been identified. By contrast, the area remains more obscure for unconventional, innate-like γδ T cells, as the literature has been scarce and at times contradictory. Here we review the current state of the art on the costimulatory requirements of γδ T cell activation. We highlight the roles of members of the immunoglobulin (like CD28 or JAML) or tumour necrosis factor receptor (like CD27) superfamilies of coreceptors, but also of more atypical costimulatory molecules, such as NKG2D or CD46. Finally, we identify various areas where our knowledge is still markedly insufficient, hoping to provoke future research on γδ T cell costimulation.pt_PT
dc.description.sponsorshipEuropean Molecular Biology Organisation (Installation Grant, project no. 1440) and Fundação para a Ciência e Tecnologia (PTDC/SAU-MII/ 104158/ 2008) for funding.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCell Mol Life Sci. 2011 Jul;68(14):2345-2355pt_PT
dc.identifier.doi10.1007/s00018-011-0698-2pt_PT
dc.identifier.eissn1420-9071
dc.identifier.issn1420-682X
dc.identifier.urihttp://hdl.handle.net/10451/49681
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/18pt_PT
dc.subjectγδ T cellspt_PT
dc.subjectT cell activationpt_PT
dc.subjectCostimulationpt_PT
dc.subjectCD27pt_PT
dc.subjectCD28pt_PT
dc.subjectNKG2Dpt_PT
dc.titleSearching for “signal 2”: costimulation requirements of γδ T cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-MII%2F104158%2F2008/PT
oaire.citation.endPage2355pt_PT
oaire.citation.issue14pt_PT
oaire.citation.startPage2345pt_PT
oaire.citation.titleCellular and Molecular Life Sciencespt_PT
oaire.citation.volume68pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameRibot
person.familyNameSilva-Santos
person.givenNameJulie Cécile Caroline
person.givenNameBruno
person.identifier.ciencia-id7C1C-F771-97C9
person.identifier.ciencia-idD51E-6517-BE6A
person.identifier.orcid0000-0002-7852-343X
person.identifier.orcid0000-0003-4141-9302
person.identifier.scopus-author-id6505885924
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication482485cc-47d9-42dd-98e7-df1e2636f071
relation.isAuthorOfPublicationf313ff02-41ee-4014-88a1-bd641b6219bf
relation.isAuthorOfPublication.latestForDiscovery482485cc-47d9-42dd-98e7-df1e2636f071
relation.isProjectOfPublicationffcc5777-29d0-4179-9565-17b5629abd65
relation.isProjectOfPublication.latestForDiscoveryffcc5777-29d0-4179-9565-17b5629abd65

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