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The Perfect Condition for the Rising of Superbugs: Person-to-Person Contact and Antibiotic Use Are the Key Factors Responsible for the Positive Correlation between Antibiotic Resistance Gene Diversity and Virulence Gene Diversity in Human Metagenomes

2021-05-21Journal article Open access
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dc.contributor.authorDomingues, Célia P. F.
dc.contributor.authorRebelo, João S.
dc.contributor.authorPothier, Joel
dc.contributor.authorMonteiro, Francisca
dc.contributor.authorNogueira, Teresa
dc.contributor.authorDionisio, Francisco
dc.date.accessioned2021-05-31T12:57:50Z
dc.date.available2021-05-31T12:57:50Z
dc.date.issued2021-05-21
dc.description.abstractHuman metagenomes with a high diversity of virulence genes tend to have a high diversity of antibiotic-resistance genes and vice-versa. To understand this positive correlation, we simulated the transfer of these genes and bacterial pathogens in a community of interacting people that take antibiotics when infected by pathogens. Simulations show that people with higher diversity of virulence and resistance genes took antibiotics long ago, not recently. On the other extreme, we find people with low diversity of both gene types because they took antibiotics recently—while antibiotics select specific resistance genes, they also decrease gene diversity by eliminating bacteria. In general, the diversity of virulence and resistance genes becomes positively correlated whenever the transmission probability between people is higher than the probability of losing resistance genes. The positive correlation holds even under changes of several variables, such as the relative or total diversity of virulence and resistance genes, the contamination probability between individuals, the loss rate of resistance genes, or the social network type. Because the loss rate of resistance genes may be shallow, we conclude that the transmission between people and antibiotic usage are the leading causes for the positive correlation between virulence and antibiotic-resistance genes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDomingues, C.P.F.; Rebelo, J.S.; Pothier, J.; Monteiro, F.; Nogueira, T.; Dionisio, F. The Perfect Condition for the Rising of Superbugs: Person-to-Person Contact and Antibiotic Use Are the Key Factors Responsible for the Positive Correlation between Antibiotic Resistance Gene Diversity and Virulence Gene Diversity in Human Metagenomes. Antibiotics 2021, 10, 605. https://doi.org/10.3390/antibiotics10050605pt_PT
dc.identifier.doihttps://doi.org/10.3390/antibiotics10050605pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/48258
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationALG-01-0145-FEDER-028824pt_PT
dc.relationFCT PTDC/BIAMIC/ 28824/2017pt_PT
dc.relationFCT SFRH/BPD/123504/2016pt_PT
dc.relationFCT UIDP/00329/2020pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectantibiotic resistance; virulence; microbiome; metagenomics; human gut; computer simulationpt_PT
dc.titleThe Perfect Condition for the Rising of Superbugs: Person-to-Person Contact and Antibiotic Use Are the Key Factors Responsible for the Positive Correlation between Antibiotic Resistance Gene Diversity and Virulence Gene Diversity in Human Metagenomespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.startPage605pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume5pt_PT
person.familyNameDomingues
person.familyNameRebelo
person.familyNamePothier
person.familyNameSarreira Simões Horta Monteiro
person.familyNameVitorino Nogueira
person.familyNameDionísio
person.givenNameCélia
person.givenNameJoão
person.givenNameJoel
person.givenNameFrancisca
person.givenNameTeresa Isabel
person.givenNameFrancisco
person.identifierG-2273-2010
person.identifierA-2129-2009
person.identifier.ciencia-id3416-6299-1379
person.identifier.ciencia-idA015-FF75-397C
person.identifier.ciencia-idA815-CE3A-53C9
person.identifier.ciencia-idF211-4E18-2C69
person.identifier.ciencia-id7413-DB46-16E0
person.identifier.orcid0000-0003-2970-010X
person.identifier.orcid0000-0002-8662-7378
person.identifier.orcid0000-0002-4021-6055
person.identifier.orcid0000-0002-5275-714X
person.identifier.orcid0000-0002-0059-5177
person.identifier.orcid0000-0002-3653-1511
person.identifier.scopus-author-id7004351448
person.identifier.scopus-author-id6506790127
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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