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Multi-drug and beta-lactam resistance in Escherichia coli and food-borne pathogens from animals and food in Portugal, 2014-2019

2022-01-12Journal article Open access
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dc.contributor.authorCosta, Miguel Mendes
dc.contributor.authorCardo, Miguel
dc.contributor.authorSoares, Patricia
dc.contributor.authorCara d'Anjo, Maria
dc.contributor.authorLeite, Andreia
dc.date.accessioned2022-05-15T21:34:48Z
dc.date.available2022-05-15T21:34:48Z
dc.date.issued2022-01-12
dc.descriptionResearch Areas: Infectious Diseases ; Pharmacology & Pharmacypt_PT
dc.description.abstractAnimal and food sources are seen as a potential transmission pathway of antimicrobial resistance (AMR) to humans. The aim of this study is to describe Campylobacter, Salmonella, and commensal Escherichia coli multi-drug resistance (MDR) in the food chain between 2014 and 2019 in Portugal. AMR surveillance data from food-producing animals and food were assessed. MDR relative frequencies were estimated by bacterial genus and year. AMR profiles were created using observations of resistance to antimicrobial classes from each isolate. Antimicrobial susceptibility testing results were clustered using k-modes. Clusters were described by population, AMR classification, β-lactamases, sample stage, sample type, season, and year. Overall, MDR was more prevalent for E. coli, ranging from 74–90% in animal and 94–100% in food samples. MDR was found to be more widespread in resistance profiles that were common among E. coli and Salmonella isolates and in those exclusively observed for E. coli, frequently including (fluoro)quinolones and cephalosporins resistance. β-lactam resistance was observed around 75% to 3rd/4th-generation cephalosporins in E. coli. Clusters suggest an escalating MDR behaviour from farm to post-farm stages in all bacteria and that Salmonella (fluoro)quinolones resistance may be associated with broilers. These findings support policy and decision making to tackle MDR in farm and post-farm stagespt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta M, Cardo M, Soares P, Cara d’Anjo M, Leite A. 2022. Multi-drug and beta-lactam resistance in Escherichia coli and food-borne pathogens from animals and food in Portugal, 2014-2019. Antibiotics 11(1):90. DOI 10.3390/ antibiotics11010090pt_PT
dc.identifier.doi10.3390/ antibiotics11010090pt_PT
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/10400.5/24311
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
dc.relationAntimicrobial Resistance and Zoonoses: One Health Challenge
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/11/1/90pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMulti-drug resistancept_PT
dc.subjectFood-producing animalspt_PT
dc.subjectZoonotic bacteriapt_PT
dc.subjectFood safetypt_PT
dc.subjectSurveillancept_PT
dc.titleMulti-drug and beta-lactam resistance in Escherichia coli and food-borne pathogens from animals and food in Portugal, 2014-2019pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleComprehensive Health Research Center - Research, Education, Training and Innovation in Clinical research and Public Health
oaire.awardTitleAntimicrobial Resistance and Zoonoses: One Health Challenge
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04923%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F135759%2F2018/PT
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume11(1):90pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication919196a0-040d-4895-a2fd-17799fff82f9
relation.isProjectOfPublicationc5cbd417-53fe-45c8-8470-d20313e8cb6b
relation.isProjectOfPublication.latestForDiscovery919196a0-040d-4895-a2fd-17799fff82f9

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