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Estudo dos doentes com sarcoma de Kaposi após a introdução da terapêutica HAART nos últimos 19 anos no Hospital de Santa Maria - Lisboa (1994-2012)
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Resumo(s)
O Sarcoma de Kaposi é um tumor vascular de baixa malignidade que atinge principalmente a pele, causado por HHV-8. O HHV-8 encontra-se distribuído em todo o mundo, sendo endémico em alguns países africanos. As suas vias de transmissão ainda não estão bem estabelecidas, mas a transmissão através da saliva parece ter um papel importante na sua disseminação. O Sarcoma de Kaposi apresenta quatro formas de acordo com a epidemiologia, a clássica, endémica africana, iatrogénica e associada à SIDA/VIH. O objetivo deste estudo foi avaliar o perfil epidemiológico dos doentes com SK no Hospital de Santa Maria em Lisboa e comparar os dados à literatura existente. Para isso, foram colhidos dados dos processos clínicos dos doentes com diagnóstico histológico de Sarcoma de Kaposi entre os anos de 1994 e 2012. A forma do tumor com mais casos na população estudada foi a associada à SIDA/VIH, seguida das formas clássica, iatrogénica e endémica africana. Foi observado aumento progressivo do número de casos nos últimos anos em todas as formas epidemiológicas. A imunossupressão parece ter sido um dos principais fatores associados à doença nos doentes com infeção por VIH e os tratamentos que melhoraram a imunidade dos doentes, independente da forma epidemiológica, foram os que obtiveram melhores resultados em relação à estabilização ou cura das lesões.
Kaposi's Sarcoma is a low-grade malignant tumor of vascular origin that affects primarily the skin. It is caused by HHV-8. HHV-8 can be found in all continents, but is endemic in some African countries. Its transmission routes are not yet well estabilished, but it seems that transmission through saliva plays an important role in its dissemination. Kaposi's Sarcoma has four epidemiological variants, classic, African endemic, iatrogenic and AIDS/HIV associated. The objective of this study was to analize the epidemiological data of Hospital Santa Maria's patients and compare it with the literature. In order to do that, clinical data were collected from all the individuals with histologically confirmed diagnosis of Kaposi's Sarcoma between the years of 1994 and 2012. Most cases in the study corresponded to the AIDS/HIV associated variant, followed by the classical, iatrogenic and African endemic variants. In all variants, the number of cases progressively increased over the years in the population of the study. Imunossupression seems to have been the most important factor associated with the AIDS/HIV associated variant and the treatments that improved host immunity were the ones with the best outcomes when it came to lesion stabilization or cure.
Kaposi's Sarcoma is a low-grade malignant tumor of vascular origin that affects primarily the skin. It is caused by HHV-8. HHV-8 can be found in all continents, but is endemic in some African countries. Its transmission routes are not yet well estabilished, but it seems that transmission through saliva plays an important role in its dissemination. Kaposi's Sarcoma has four epidemiological variants, classic, African endemic, iatrogenic and AIDS/HIV associated. The objective of this study was to analize the epidemiological data of Hospital Santa Maria's patients and compare it with the literature. In order to do that, clinical data were collected from all the individuals with histologically confirmed diagnosis of Kaposi's Sarcoma between the years of 1994 and 2012. Most cases in the study corresponded to the AIDS/HIV associated variant, followed by the classical, iatrogenic and African endemic variants. In all variants, the number of cases progressively increased over the years in the population of the study. Imunossupression seems to have been the most important factor associated with the AIDS/HIV associated variant and the treatments that improved host immunity were the ones with the best outcomes when it came to lesion stabilization or cure.
Descrição
Tese de mestrado, Doenças Infecciosas Emergentes, Faculdade de Medicina, Universidade de Lisboa, 2014
Palavras-chave
Sarcoma de Kaposi Vascular HHV-8 VIH Teses de mestrado - 2014