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Antibody approaches to treat brain diseases

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dc.contributor.authorNeves, Vera
dc.contributor.authorSilva, Frederico Aires da
dc.contributor.authorReal, Sofia Corte
dc.contributor.authorCastanho, Miguel A. R. B.
dc.date.accessioned2018-04-16T13:28:06Z
dc.date.available2018-04-16T13:28:06Z
dc.date.issued2016
dc.description© 2015 Elsevier Ltd.pt_PT
dc.description.abstractRecombinant antibodies are an emerging class of therapeutics with substantial promise to treat central nervous system (CNS) diseases such as Alzheimer's, Parkinson's, stroke, and brain cancers. However, poor blood–brain barrier (BBB) permeability hinders the progress of antibody therapies for conditions in which the target is located in the brain. Nonetheless, antibodies can nowa-days be engineered to enhance their therapeutic applications and translocation of the BBB using the natural portals of the brain. This paper reviews advances in the development and engineering of therapeutic BBB-crossing antibodies and their high potential for treatment of CNS disorders.pt_PT
dc.description.sponsorshipThe authors thank Portuguese Funding scheme (Fundação para a Ciência e Tecnologia, FCT) for financial support (grants SFRH/BPD/94466/2013; IF/01010/2013); and Marie Skłodowska-Curie Research and Innovation Staff Exchange (MSCA-RISE), call H2020-MSCA-RISE-2014 (grant agreement 644167 – INPACT). The authors declare no conflicts of interest.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTrends in Biotechnology, January 2016, Vol. 34, No. 1pt_PT
dc.identifier.doi10.1016/j.tibtech.2015.10.005pt_PT
dc.identifier.issn0167-7799
dc.identifier.urihttp://hdl.handle.net/10451/32815
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIF/01010/2013pt_PT
dc.relationPeptides for blood-brain barrier transmigration and drug delivery - novel therapies for the central nervous system CNS
dc.relation.publisherversionhttps://www.journals.elsevier.com/trends-in-biotechnologypt_PT
dc.titleAntibody approaches to treat brain diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePeptides for blood-brain barrier transmigration and drug delivery - novel therapies for the central nervous system CNS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F94466%2F2013/PT
oaire.citation.endPage48pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage36pt_PT
oaire.citation.titleTrends in Biotechnologypt_PT
oaire.citation.volume34pt_PT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication4b808757-8ecf-4878-8587-418aa9007bfb
relation.isProjectOfPublication.latestForDiscovery4b808757-8ecf-4878-8587-418aa9007bfb

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