Antibody approaches to treat brain diseases

Neves, Vera; Silva, Frederico Aires da; Real, Sofia Corte; Castanho, Miguel A. R. B.

http://hdl.handle.net/10451/32815

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Authors

Neves, Vera

Silva, Frederico Aires da

Real, Sofia Corte

Castanho, Miguel A. R. B.

Abstract(s)

Recombinant antibodies are an emerging class of therapeutics with substantial promise to treat central nervous system (CNS) diseases such as Alzheimer's, Parkinson's, stroke, and brain cancers. However, poor blood–brain barrier (BBB) permeability hinders the progress of antibody therapies for conditions in which the target is located in the brain. Nonetheless, antibodies can nowa-days be engineered to enhance their therapeutic applications and translocation of the BBB using the natural portals of the brain. This paper reviews advances in the development and engineering of therapeutic BBB-crossing antibodies and their high potential for treatment of CNS disorders.

Description

URI

http://hdl.handle.net/10451/32815

Citation

Trends in Biotechnology, January 2016, Vol. 34, No. 1

Research Projects

Peptides for blood-brain barrier transmigration and drug delivery - novel therapies for the central nervous system CNS

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Publisher

Elsevier

DOI

10.1016/j.tibtech.2015.10.005

Collections

IMM - Artigos em Revistas Internacionais

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