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Profile of cognitive impairment in late‐stage Parkinson's disease

2022Artigo científico Acesso aberto
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dc.contributor.authorSeveriano e Sousa, Catarina
dc.contributor.authorFabbri, Margherita
dc.contributor.authorGodinho, Catarina
dc.contributor.authorMoiron Simões, Rita
dc.contributor.authorChendo, Inês
dc.contributor.authorCoelho, Miguel
dc.contributor.authorMartins, Isabel Pavão
dc.contributor.authorFerreira, Joaquim J
dc.date.accessioned2022-03-14T16:36:42Z
dc.date.available2022-03-14T16:36:42Z
dc.date.issued2022
dc.description© 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractIntroduction: The profile of cognitive impairment associated with the late stages of Parkinson's disease (LSPD) is rarely reported. Its characterization is necessary to better understand the cognitive changes that occur as the disease progresses and to better contribute to its management. Methods: In this cross-sectional study, we characterized the cognitive profile of LSPD patients using the comprehensive assessment methodology proposed by the International Parkinson and Movement Disorders Society Task Force. The association of clinical and demographic variables with dementia diagnosis was also investigated using binary logistic regression analysis. Results: Eighty-four LSPD patients were included (age 75.4 ± 6.9; disease duration 16.9 ± 7.5). Fifty-four (64.3%) were classified as demented and presented a global impairment cognitive profile. In the nondemented group (N = 30), 25 (83.3%) LSPD patients met the diagnostic criteria for mild cognitive impairment, mostly with multiple domain impairment (96.0%) and a heterogeneous profile. Memory was the most frequent and severely impaired cognitive domain in both groups. Disease disability, orientation, complex order comprehension, verbal learning, and visuoconstructive abilities were significantly associated with dementia diagnosis (p < .05). Conclusions: Cognitive impairment in multiple domains was common in LSPD patients. The most frequent and prominent deficits were in the memory domain, with a strong interference from attention impairment. Disease disability, orientation, complex order comprehension, verbal learning, and visuoconstructive abilities proved to be important determinants for dementia diagnosis.pt_PT
dc.description.sponsorshipThis work was supported by a doctoral fellowship (SFRH/BD/139853/2018) from Fundação para a Ciência e Tecnologia, Portugal, which was assigned to Catarina Severiano e Sousa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBrain Behav. 2022;32537pt_PT
dc.identifier.doi10.1002/brb3.2537pt_PT
dc.identifier.eissn2157-9032
dc.identifier.issn2162-3279
dc.identifier.urihttp://hdl.handle.net/10451/51733
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationCognitive Disorders in Late-Stage Parkinson´s Disease
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/21579032pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectParkinson's diseasept_PT
dc.subjectCognitive impairmentpt_PT
dc.subjectLate-stagept_PT
dc.titleProfile of cognitive impairment in late‐stage Parkinson's diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCognitive Disorders in Late-Stage Parkinson´s Disease
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F139853%2F2018/PT
oaire.citation.titleBrain and Behaviorpt_PT
oaire.fundingStreamOE
person.familyNameFabbri
person.familyNameCoelho
person.familyNamePavão Martins
person.familyNameFerreira
person.givenNameMargherita
person.givenNameMiguel
person.givenNameIsabel
person.givenNameJoaquim J
person.identifier973131
person.identifier18561
person.identifier1624753
person.identifier.ciencia-id3312-A6EB-631D
person.identifier.ciencia-id4D1D-4040-BE76
person.identifier.ciencia-id7D15-5CD6-6159
person.identifier.orcid0000-0001-7250-592X
person.identifier.orcid0000-0002-4008-8110
person.identifier.orcid0000-0002-9611-7400
person.identifier.orcid0000-0003-3950-5113
person.identifier.scopus-author-id26649410400
person.identifier.scopus-author-id7101666975
person.identifier.scopus-author-id7103152782
person.identifier.scopus-author-id7403252466
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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