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Association between the number of altered late potential criteria and increased arrhythmic risk in Brugada syndrome patients

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dc.contributor.authorBrito, Joana
dc.contributor.authorCortez-Dias, Nuno
dc.contributor.authorLima Da Silva, Gustavo
dc.contributor.authorFerreira, Afonso Nunes
dc.contributor.authorAguiar-Ricardo, Inês
dc.contributor.authorCunha, Nelson
dc.contributor.authorAntónio, Pedro Silvério
dc.contributor.authorNeves, Irina
dc.contributor.authorPaiva, Sandra
dc.contributor.authorPaixão, Ana
dc.contributor.authorGaspar, Fernanda
dc.contributor.authorSilva, Adília
dc.contributor.authorMagalhaes, Andreia
dc.contributor.authorMarques, Pedro
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorDe Sousa, João
dc.date.accessioned2023-11-28T15:03:08Z
dc.date.available2023-11-28T15:03:08Z
dc.date.issued2023
dc.description© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023pt_PT
dc.description.abstractBackground: Brugada syndrome (BrS) is associated with abnormal electrophysiological properties at right ventricular epicardium, consisting of fragmented electrograms extending well beyond QRS termination. We aimed to evaluate the utility of signal-averaged electrocardiogram (SA-ECG) for the noninvasive assessment of late potentials (LP) and risk stratification of BrS patients. Methods: A prospective, observational, single-center study of BrS patients is submitted to SA-ECG with the determination of the total filtered QRS duration (fQRS), root mean square voltage of the 40 ms terminal portion of the QRS (RMS40), and duration of the low-amplitude electric potential component of the terminal portion of the QRS (LAS40). LP were considered positive when above standard cut-offs: fQRS > 114 ms, RMS40 < 20 µV, and LAS40 > 38 ms. The rates of malignant arrhythmic events (MAEs), defined as sudden death or appropriate shocks, were compared in relation to clinical characteristics and SA-ECG findings. Results: A total of 106 BrS patients (mean age, 48 ± 12 years, 67.9% male) were studied, 49% with type-1 spontaneous pattern and 81% asymptomatic. During a median follow up of 4.7 years, 10 patients (7.1%) suffered MAEs, including 4 sudden deaths. The presence of LP was significantly associated with the arrhythmic risk, which increased with the number of altered LP criteria. In comparison to the patients who had none or 1 altered LP criterium, MAE risk was 4.7 times higher in those with 2 altered criteria and 9.4 times higher in those with 3 altered LP criteria. Conclusions: SA-ECG may be a useful tool for risk stratification in BrS. The presence of 2 or 3 abnormal LP criteria could identify a subset of asymptomatic patients at high risk of arrhythmic events.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Interv Card Electrophysiol. 2023 Nov 15pt_PT
dc.identifier.doi10.1007/s10840-023-01685-8pt_PT
dc.identifier.eissn1572-8595
dc.identifier.issn1383-875X
dc.identifier.urihttp://hdl.handle.net/10451/60955
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://link.springer.com/journal/10840pt_PT
dc.subjectBrugada syndromept_PT
dc.subjectLate potentialspt_PT
dc.subjectSignal-averaged ECGpt_PT
dc.titleAssociation between the number of altered late potential criteria and increased arrhythmic risk in Brugada syndrome patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Interventional Cardiac Electrophysiologypt_PT
person.familyNameBrito
person.familyNameCortez-Dias
person.familyNameLima da Silva
person.familyNameNunes-Ferreira
person.familyNameAguiar-Ricardo
person.familyNamePires da Cunha
person.familyNameMagalhaes
person.familyNamePinto
person.familyNamede Sousa
person.givenNameJoana
person.givenNameNuno
person.givenNameGustavo
person.givenNameAfonso
person.givenNameInês
person.givenNameNelson
person.givenNameAndreia
person.givenNameFausto J.
person.givenNameJoão
person.identifier1308889
person.identifier.ciencia-id281C-A194-3753
person.identifier.ciencia-idD612-D3C3-6E1D
person.identifier.ciencia-idFB15-EB01-5F40
person.identifier.ciencia-id0419-C014-BA22
person.identifier.ciencia-idD012-F874-3DA7
person.identifier.ciencia-idC31A-891E-18DD
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.ciencia-id7D1D-FC15-13D6
person.identifier.orcid0000-0001-6672-7542
person.identifier.orcid0000-0002-9244-4631
person.identifier.orcid0000-0003-3138-8354
person.identifier.orcid0000-0002-2836-9497
person.identifier.orcid0000-0002-9951-1104
person.identifier.orcid0000-0002-4638-990X
person.identifier.orcid0000-0002-8034-4529
person.identifier.orcid0000-0003-2782-8214
person.identifier.ridH-8224-2016
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id7102740158
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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