Publication
Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
| dc.contributor.author | Cavaleiro, R. | |
| dc.contributor.author | Tendeiro, R. | |
| dc.contributor.author | Foxall, R. B. | |
| dc.contributor.author | Soares, R. S. | |
| dc.contributor.author | Baptista, A. P. | |
| dc.contributor.author | Gomes, P. | |
| dc.contributor.author | Valadas, Emília | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-06-17T13:42:26Z | |
| dc.date.available | 2015-06-17T13:42:26Z | |
| dc.date.issued | 2013 | |
| dc.description | © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. | eng |
| dc.description.abstract | Monocytes and myeloid dendritic cells (mDCs) are important orchestrators of innate and human immunodeficiency virus (HIV)-specific immune responses and of the generalized inflammation that characterizes AIDS progression. To our knowledge, we are the first to investigate monocyte and mDC imbalances in HIV type 2 (HIV-2)-positive patients, who typically feature reduced viremia and slow disease progression despite the recognized ability of HIV-2 to establish viral reservoirs and overcome host restriction factors in myeloid cells. We found a heightened state of monocyte and mDC activation throughout HIV-2 infection (characterized by CD14(bright)CD16(+) expansion, as well as increased levels of soluble CD14, HLA-DR, and CD86), together with progressive mDC depletion. Importantly, HIV-2-positive patients also featured overexpression of the inhibitory molecule PD-L1 on monocytes and mDCs, which may act by limiting the production of proinflammatory molecules. These data, from patients with a naturally occurring form of attenuated HIV disease, challenge current paradigms regarding the role of monocytes in HIV/AIDS and open new perspectives regarding potential strategies to modulate inflammatory states. | por |
| dc.description.sponsorship | This work was supported by the Fundação para a Ciência e a Tecnologia (scholarships to R. C., R. T., R. B. F. and R. S. S.), the Programa Operacional Ciência e Inovação 2010, and the Fundação Calouste Gulbenkian (to A. E. S.). | eng |
| dc.identifier.citation | JID 2013:207 (1 June) | por |
| dc.identifier.isbn | 0022-1899 | |
| dc.identifier.uri | http://jid.oxfordjournals.org/content/207/11/1730.long | |
| dc.identifier.uri | http://dx.doi.org/ 10.1093/infdis/jit085 | |
| dc.identifier.uri | http://hdl.handle.net/10451/18303 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.relation.publisherversion | The definitive version is available at http://www.oxfordjournals.org/en/ | eng |
| dc.subject | HIV-2 | eng |
| dc.subject | AIDS | eng |
| dc.subject | Monocytes | eng |
| dc.subject | Myeloid dendritic cells | eng |
| dc.subject | PD-L1 | eng |
| dc.subject | Immune activation | eng |
| dc.title | Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease. | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Journal of Infectious Diseases | eng |
| person.familyName | Valadas | |
| person.givenName | Emília | |
| person.identifier.orcid | 0000-0001-5213-1473 | |
| person.identifier.scopus-author-id | 6603593138 | |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | 5eb6f5fc-a01f-4938-832e-bad672e8c877 | |
| relation.isAuthorOfPublication.latestForDiscovery | 5eb6f5fc-a01f-4938-832e-bad672e8c877 |