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Parasite glycobiology: a bittersweet symphony
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Orientador(es)
Resumo(s)
Human infections caused by parasitic protozoans and helminths are among the world's leading causes of death. More than a million people die each year from diseases like malaria and neglected tropical diseases like leishmaniasis, trypanosomiasis, and schistosomiasis. Patients also endure disabilities that cause lifelong suffering and that affect productivity and development. More insidiously, parasites generate important economic losses, since they often also infect commercially valuable animals. Worldwide, exposure to parasites is increasing due to growing international travel and migrations, as well as climate changes, which affect the geographic distribution of the parasite vectors. The parasitic threat is also aggravated by the rise of the immunocompromised population, which is particularly sensitive to parasite infections (e.g., individuals with AIDS and other immunodeficiencies).
Descrição
Copyright: © 2015 Rodrigues et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Palavras-chave
Parasitic diseases Nucleotides Glycosylation Enzyme structure Host-pathogen interactions Biosynthesis Glycosyltransferases Protozoan infections
Contexto Educativo
Citação
PLoS Pathog. 2015 Nov 12;11(11):e1005169
Editora
PLOS