Publicação
Cyclotides as templates in drug design
| dc.contributor.author | Henriques, Sónia Troeira | |
| dc.contributor.author | Craik, David J. | |
| dc.date.accessioned | 2013-01-31T18:00:45Z | |
| dc.date.available | 2013-01-31T18:00:45Z | |
| dc.date.issued | 2010 | |
| dc.description | © 2009 Elsevier Ltd. All rights reserved | eng |
| dc.description.abstract | Cyclotides are remarkably stable proteins from plants that have a range of pharmaceutical and agricultural applications based on both their various bioactivities and their potential for use as stable protein-engineering templates. This article discusses literature on pharmaceutically relevant activities of cyclotides, including anti-HIV, antimicrobial and cytotoxic activities, and evaluates their potential therapeutic applications. Their applications as templates for the design of antiangiogenic agents for the treatment of cancer and as anti-infective agents are also described. Toxic effects of cyclotides, whose native function is as insecticidal agents, can be removed by simple mutagenesis, thus rationalizing the apparent conundrum of proposing insecticidal agents as leads for human therapeutics. | eng |
| dc.description.sponsorship | Studies in our laboratory on cyclotides are supported by grants from the Australian Research Council (DP0880105) and the National Health and Medical Research Council (NHMRC). D.J.C. is an NHMRC Professorial Fellow. S.T.H. is a Marie Curie Postdoctoral Fellowawarded by EuropeanCommission (PIOF-GA-2008-220318). | eng |
| dc.identifier.citation | Drug Discovery Today . Volume 15, Numbers 1/2 ∙ January 2010 | eng |
| dc.identifier.issn | 1359-6446 | |
| dc.identifier.uri | http://dx.doi.org/10.1016/j.drudis.2009.10.007 | |
| dc.identifier.uri | http://hdl.handle.net/10451/7619 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.relation.publisherversion | The definitive version is available at http://www.elsevier.com/ | eng |
| dc.title | Cyclotides as templates in drug design | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 64 | por |
| oaire.citation.startPage | 57 | por |
| oaire.citation.title | Drug Discovery Today | eng |
| oaire.citation.volume | 15 | por |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | article | por |