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Non-Tuberculous Mycobacteria: Molecular and Physiological Bases of Virulence and Adaptation to Ecological Niches

2020-09Artigo científico Acesso aberto
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dc.contributor.authorPereira, André C.
dc.contributor.authorRamos, Beatriz
dc.contributor.authorReis, Ana C.
dc.contributor.authorCunha, Mónica V.
dc.date.accessioned2021-01-31T14:28:19Z
dc.date.available2021-01-31T14:28:19Z
dc.date.issued2020-09
dc.description.abstractNon-tuberculous mycobacteria (NTM) are paradigmatic colonizers of the total environment, circulating at the interfaces of the atmosphere, lithosphere, hydrosphere, biosphere, and anthroposphere. Their striking adaptive ecology on the interconnection of multiple spheres results from the combination of several biological features related to their exclusive hydrophobic and lipid-rich impermeable cell wall, transcriptional regulation signatures, biofilm phenotype, and symbiosis with protozoa. This unique blend of traits is reviewed in this work, with highlights to the prodigious plasticity and persistence hallmarks of NTM in a wide diversity of environments, from extreme natural milieus to microniches in the human body. Knowledge on the taxonomy, evolution, and functional diversity of NTM is updated, as well as the molecular and physiological bases for environmental adaptation, tolerance to xenobiotics, and infection biology in the human and non-human host. The complex interplay between individual, species-specific and ecological niche traits contributing to NTM resilience across ecosystems are also explored. This work hinges current understandings of NTM, approaching their biology and heterogeneity from several angles and reinforcing the complexity of these microorganisms often associated with a multiplicity of diseases, including pulmonary, soft-tissue, or milliary. In addition to emphasizing the cornerstones of knowledge involving these bacteria, we identify research gaps that need to be addressed, stressing out the need for decision-makers to recognize NTM infection as a public health issue that has to be tackled, especially when considering an increasingly susceptible elderly and immunocompromised population in developed countries, as well as in low- or middle-income countries, where NTM infections are still highly misdiagnosed and neglected.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira, A.C., Ramos, B., Reis, A.C. & Cunha, M.V. (2020) Non-tuberculous mycobacteria: molecular and physiological bases of virulence and adaptation to ecological niches. Microorganisms, 8(9), 1380. DOI:10.3390/microorganisms8091380pt_PT
dc.identifier.doi10.3390/microorganisms8091380pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/46088
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPOCI-01-0145-FEDER029783pt_PT
dc.relationMyPATH- Insights into Mycobacterium tuberculosis complex PATHogenesis: assessing the benefit of confinement-induced biofilm strategies by comparative genomics
dc.relationCentre for Ecology, Evolution and Environmental Changes
dc.relationSystems epidemiology to devise new interventions for multi-host tuberculosis
dc.relationIncorporating the genomic signature of environmental Mycobacterium bovis into transmission models of animal TB under a phylodynamics conceptual framework
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleNon-Tuberculous Mycobacteria: Molecular and Physiological Bases of Virulence and Adaptation to Ecological Nichespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMyPATH- Insights into Mycobacterium tuberculosis complex PATHogenesis: assessing the benefit of confinement-induced biofilm strategies by comparative genomics
oaire.awardTitleCentre for Ecology, Evolution and Environmental Changes
oaire.awardTitleSystems epidemiology to devise new interventions for multi-host tuberculosis
oaire.awardTitleIncorporating the genomic signature of environmental Mycobacterium bovis into transmission models of animal TB under a phylodynamics conceptual framework
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT%2F117794%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00329%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/PD%2FBD%2F128031%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F136557%2F2018/PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1380pt_PT
oaire.citation.titleMicroorganismspt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
person.familyNameCunha
person.givenNameMonica V.
person.identifier348477
person.identifier.ciencia-id5616-E715-2F31
person.identifier.orcid0000-0003-0401-0276
person.identifier.ridD-5544-2011
person.identifier.scopus-author-id7102711216
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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