p53 mutations are common in human papillomavirus type 38-positive non-melanoma skin cancers

Caldeira, Sandra; Filotico, Raffaele; Accardi, Rosita; Zehbe, Ingeborg; Franceschi, Silvia; Tommasino, Massimo

http://hdl.handle.net/10451/47647

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Resumo(s)

In cervical cells, the E6 protein of the oncogenic human papillomavirus (HPV) types inactivates p53, promoting its degradation. Consequently, mutations of the p53 gene are rarely seen in these cancers. Our recent data indicate that the cutaneous HPV38 is involved in skin carcinogenesis. In this study, we have determined the presence of HPV38 and the status of p53 gene in 32 non-melanoma skin cancers. We found that p53 gene is frequently mutated in HPV38-positive skin cancers and that HPV38 E6 does not promote p53 degradation. Thus, different mechanisms appear to be involved in the development of HPV-positive cervical and skin cancers.

Descrição

Palavras-chave

Non-melanoma-skin cancer Human papillomavirus E6 p53

URI

http://hdl.handle.net/10451/47647

Citação

Cancer Lett. 2004 Jun 8;209(1):119-124

Editora

Elsevier

DOI

10.1016/j.canlet.2003.12.003

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais

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