Publicação
Long-term locoregional recurrence in patients treated for breast cancer
| dc.contributor.author | Costeira, Beatriz | |
| dc.contributor.author | da Silva, Francisca Brito | |
| dc.contributor.author | Fonseca, Filipa | |
| dc.contributor.author | Oom, Rodrigo | |
| dc.contributor.author | Costa, Cristina | |
| dc.contributor.author | Moniz, João Vargas | |
| dc.contributor.author | Abecasis, Nuno | |
| dc.contributor.author | Santos, Catarina Rodrigues | |
| dc.date.accessioned | 2023-10-27T11:40:10Z | |
| dc.date.available | 2023-10-27T11:40:10Z | |
| dc.date.issued | 2023 | |
| dc.description | © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | pt_PT |
| dc.description.abstract | Background/purpose: Locoregional control in breast cancer is a fundamental part of treatment and determinant for survival outcomes. It has been reported that most locoregional recurrence (LRR) events occur in the first 5 years after treatment. However, LRR continue to occur after this timeline, with unclear risk factors and unknown survival impact. Methods: Retrospective singe-centered cohort of patients treated for primary breast cancer, between January 2002 and December 2004. Primary outcome was LRR; secondary outcomes were overall survival (OS), disease-free survival (DFS), and predictive factors for LRR. Results: This analysis included 1001 patients, of which 959 (95%) had invasive carcinoma. A mastectomy was performed in 501 (50%) and 500 (50%) had breast conservative surgery (BCS). Median follow-up time was 197 [Inter-quartile range (IQR) 96-211] months. Global LRR rate was 7.6%, with median time to recurrence of 45 [IQR 21-91] months. There was no difference in LRR rate after mastectomy vs BCS, adjusted to tumor stage (p > 0.05). The 10-year OS and DFS rates were 68.4 and 77.8%, respectively. Factors associated with LRR were metastatic axillary lymph nodes and high histologic grade (p < 0.05). Estrogen-negative (ER) tumors had higher LRR rates than ER-positive tumors in the first 5 years (p < 0.05); but no difference was observed with longer follow-up (p > 0.05). LRR was associated with OS (p < 0.05). Discussion and conclusions: Global LRR in this cohort was 7.6% (with over 16 years of follow-up). LRR associates with decreased OS. Time to LRR varies significantly with tumor biology, supporting differentiation of follow-up regimens. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Breast Cancer Res Treat. 2023 Dec;202(3):551-561 | pt_PT |
| dc.identifier.doi | 10.1007/s10549-023-07089-6 | pt_PT |
| dc.identifier.eissn | 1573-7217 | |
| dc.identifier.issn | 0167-6806 | |
| dc.identifier.uri | http://hdl.handle.net/10451/60033 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Springer Nature | pt_PT |
| dc.relation.publisherversion | https://www.springer.com/journal/10549 | pt_PT |
| dc.subject | Breast neoplasm | pt_PT |
| dc.subject | Breast-conserving surgery | pt_PT |
| dc.subject | Local neoplasm recurrence | pt_PT |
| dc.subject | Mastectomy | pt_PT |
| dc.subject | Survival Analysis | pt_PT |
| dc.title | Long-term locoregional recurrence in patients treated for breast cancer | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 561 | pt_PT |
| oaire.citation.issue | 3 | pt_PT |
| oaire.citation.startPage | 551 | pt_PT |
| oaire.citation.title | Breast Cancer Research and Treatment | pt_PT |
| oaire.citation.volume | 202 | pt_PT |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |